Voxel-based morphometry of human brain with age and cerebrovascular risk factors

Yasuyuki Taki, Ryoui Goto, Alan Evans, Alex Zijdenbos, Peter Neelin, Jason Lerch, Kazunori Sato, Shuichi Ono, Shigeo Kinomura, Manabu Nakagawa, Motoaki Sugiura, Jobu Watanabe, Ryuta Kawashima, Hiroshi Fukuda

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132 Citations (Scopus)

Abstract

The objectives of this study were to evaluate the correlations of the volumes of the gray matter and white matter with age, and the correlations of the tissue probabilities of the gray matter and white matter with age and several cerebrovascular risk factors. We obtained magnetic resonance (MR) images of the brain and clinical information from 769 normal Japanese subjects. We processed the MR images automatically by correcting for inter-individual differences in brain size and shape, and by segmenting the MR images into the gray matter and white matter. Volumetry of the brain revealed a significant negative correlation between the gray matter volume and age, which was not observed between white matter volume and age. Voxel-based morphometry showed that age, systolic blood pressure, and alcohol drinking correlated with the regional tissue probabilities of the gray matter and white matter.

Original languageEnglish
Pages (from-to)455-463
Number of pages9
JournalNeurobiology of Aging
Volume25
Issue number4
DOIs
Publication statusPublished - 2004 Apr 1

Keywords

  • Age
  • Cerebrovasucular risk factors
  • Gray matter
  • MRI
  • Voxel-based morphometry
  • White matter

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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    Taki, Y., Goto, R., Evans, A., Zijdenbos, A., Neelin, P., Lerch, J., Sato, K., Ono, S., Kinomura, S., Nakagawa, M., Sugiura, M., Watanabe, J., Kawashima, R., & Fukuda, H. (2004). Voxel-based morphometry of human brain with age and cerebrovascular risk factors. Neurobiology of Aging, 25(4), 455-463. https://doi.org/10.1016/j.neurobiolaging.2003.09.002