Voxel-based analysis of gray matter and CSF space in idiopathic normal pressure hydrocephalus

Kazunari Ishii, Tetsuro Kawaguchi, Kenichi Shimada, Shingo Ohkawa, Naokazu Miyamoto, Tomonori Kanda, Takafumi Uemura, Toshiki Yoshikawa, Etsuro Mori

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)


Aims: To investigate regional morphologic changes in idiopathic normal pressure hydrocephalus (INPH) based on diagnosis with INPH Guidelines using voxel-based morphometry. Method: Three-dimensional magnetic resonance imaging was performed in 34 INPH patients, who met probable INPH criteria, probable 34 Alzheimer disease patients, and 34 normal control subjects. Results: Statistical parametric mapping was used to conduct voxel-based morphometry analysis of the morphologic data and revealed enlarged ventricles and sylvian fissures and stenotic sulci of high convexity, especially in the precuneus in the INPH group, with decreased gray matter density in the insula, caudate and thalamus. Conclusion: In INPH, morphologic change occurs in the frontoparietal high convexity with ventricular dilatations, dilated sylvian fissures and tight sulci in the medial parietal lobes.

Original languageEnglish
Pages (from-to)329-335
Number of pages7
JournalDementia and geriatric cognitive disorders
Issue number4
Publication statusPublished - 2008 Apr
Externally publishedYes


  • Alzheimer's disease
  • Idiopathic normal pressure hydrocephalus
  • Magnetic resonance imaging
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health


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