Voxel-based analysis of gray matter and CSF space in idiopathic normal pressure hydrocephalus

Kazunari Ishii; Tetsuro Kawaguchi; Kenichi Shimada; Shingo Ohkawa; Naokazu Miyamoto; Tomonori Kanda; Takafumi Uemura; Toshiki Yoshikawa; Etsuro Mori

doi:10.1159/000119521

Voxel-based analysis of gray matter and CSF space in idiopathic normal pressure hydrocephalus

Kazunari Ishii, Tetsuro Kawaguchi, Kenichi Shimada, Shingo Ohkawa, Naokazu Miyamoto, Tomonori Kanda, Takafumi Uemura, Toshiki Yoshikawa, Etsuro Mori

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

Aims: To investigate regional morphologic changes in idiopathic normal pressure hydrocephalus (INPH) based on diagnosis with INPH Guidelines using voxel-based morphometry. Method: Three-dimensional magnetic resonance imaging was performed in 34 INPH patients, who met probable INPH criteria, probable 34 Alzheimer disease patients, and 34 normal control subjects. Results: Statistical parametric mapping was used to conduct voxel-based morphometry analysis of the morphologic data and revealed enlarged ventricles and sylvian fissures and stenotic sulci of high convexity, especially in the precuneus in the INPH group, with decreased gray matter density in the insula, caudate and thalamus. Conclusion: In INPH, morphologic change occurs in the frontoparietal high convexity with ventricular dilatations, dilated sylvian fissures and tight sulci in the medial parietal lobes.

Original language	English
Pages (from-to)	329-335
Number of pages	7
Journal	Dementia and geriatric cognitive disorders
Volume	25
Issue number	4
DOIs	https://doi.org/10.1159/000119521
Publication status	Published - 2008 Apr
Externally published	Yes

Keywords

Alzheimer's disease
Idiopathic normal pressure hydrocephalus
Magnetic resonance imaging
Voxel-based morphometry

ASJC Scopus subject areas

Geriatrics and Gerontology
Cognitive Neuroscience
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000119521

Cite this

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title = "Voxel-based analysis of gray matter and CSF space in idiopathic normal pressure hydrocephalus",

abstract = "Aims: To investigate regional morphologic changes in idiopathic normal pressure hydrocephalus (INPH) based on diagnosis with INPH Guidelines using voxel-based morphometry. Method: Three-dimensional magnetic resonance imaging was performed in 34 INPH patients, who met probable INPH criteria, probable 34 Alzheimer disease patients, and 34 normal control subjects. Results: Statistical parametric mapping was used to conduct voxel-based morphometry analysis of the morphologic data and revealed enlarged ventricles and sylvian fissures and stenotic sulci of high convexity, especially in the precuneus in the INPH group, with decreased gray matter density in the insula, caudate and thalamus. Conclusion: In INPH, morphologic change occurs in the frontoparietal high convexity with ventricular dilatations, dilated sylvian fissures and tight sulci in the medial parietal lobes.",

keywords = "Alzheimer's disease, Idiopathic normal pressure hydrocephalus, Magnetic resonance imaging, Voxel-based morphometry",

author = "Kazunari Ishii and Tetsuro Kawaguchi and Kenichi Shimada and Shingo Ohkawa and Naokazu Miyamoto and Tomonori Kanda and Takafumi Uemura and Toshiki Yoshikawa and Etsuro Mori",

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doi = "10.1159/000119521",

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T1 - Voxel-based analysis of gray matter and CSF space in idiopathic normal pressure hydrocephalus

AU - Ishii, Kazunari

AU - Kawaguchi, Tetsuro

AU - Shimada, Kenichi

AU - Ohkawa, Shingo

AU - Miyamoto, Naokazu

AU - Kanda, Tomonori

AU - Uemura, Takafumi

AU - Yoshikawa, Toshiki

AU - Mori, Etsuro

PY - 2008/4

Y1 - 2008/4

N2 - Aims: To investigate regional morphologic changes in idiopathic normal pressure hydrocephalus (INPH) based on diagnosis with INPH Guidelines using voxel-based morphometry. Method: Three-dimensional magnetic resonance imaging was performed in 34 INPH patients, who met probable INPH criteria, probable 34 Alzheimer disease patients, and 34 normal control subjects. Results: Statistical parametric mapping was used to conduct voxel-based morphometry analysis of the morphologic data and revealed enlarged ventricles and sylvian fissures and stenotic sulci of high convexity, especially in the precuneus in the INPH group, with decreased gray matter density in the insula, caudate and thalamus. Conclusion: In INPH, morphologic change occurs in the frontoparietal high convexity with ventricular dilatations, dilated sylvian fissures and tight sulci in the medial parietal lobes.

AB - Aims: To investigate regional morphologic changes in idiopathic normal pressure hydrocephalus (INPH) based on diagnosis with INPH Guidelines using voxel-based morphometry. Method: Three-dimensional magnetic resonance imaging was performed in 34 INPH patients, who met probable INPH criteria, probable 34 Alzheimer disease patients, and 34 normal control subjects. Results: Statistical parametric mapping was used to conduct voxel-based morphometry analysis of the morphologic data and revealed enlarged ventricles and sylvian fissures and stenotic sulci of high convexity, especially in the precuneus in the INPH group, with decreased gray matter density in the insula, caudate and thalamus. Conclusion: In INPH, morphologic change occurs in the frontoparietal high convexity with ventricular dilatations, dilated sylvian fissures and tight sulci in the medial parietal lobes.

KW - Alzheimer's disease

KW - Idiopathic normal pressure hydrocephalus

KW - Magnetic resonance imaging

KW - Voxel-based morphometry

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Voxel-based analysis of gray matter and CSF space in idiopathic normal pressure hydrocephalus

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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