Voluntary exercise ameliorates the progression of atherosclerotic lesion formation via anti-inflammatory effects in apolipoprotein e-deficient mice

Kosuke Fukao, Kazunori Shimada, Hisashi Naito, Katsuhiko Sumiyoshi, Nao Inoue, Takafumi Lesaki, Atsumi Kume, Takashi Kiyanagi, Makoto Hiki, Kuniaki Hirose, Rie Matsumori, Hiromichi Ohsaka, Yasue Takahashi, Saori Toyoda, Seigo Itoh, Tetsuro Miyazaki, Norihiro Tada, Hiroyuki Daida

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

Aim: A sedentary lifestyle with insufficient exercise is associated with cardiovascular disease. Previous studies have demonstrated that endurance exercise benefits atherosclerosis and cardiovascular disorders; however, the mechanisms by which physical activity, such as voluntary exercise (Ex), produces these effects are not fully understood. Methods and Results: Eight-week-old male apolipoprotein (ApoE)-deficient mice were fed a standard diet (STD) or high fat diet (HFD) for 10 weeks. The HFD+Ex group mice performed Ex on a running wheel for 10 weeks. No significant differences in lipid profiles were observed between the HFD and HFD + Ex groups. Although changes in body and brown adipose tissue weights were comparable between the HFD and HFD + Ex groups, white adipose tissue weight was significantly lower in the HFD + Ex group than in the HFD group. The areas of atherosclerotic lesions in the aortic sinus and thoracoabdominal aorta were significantly reduced in the HFD + Ex group than in the HFD group (p< 0.001). There was a strong negative correlation between atherosclerotic areas and the mean running distance per day in the HFD + Ex group (r = -0.90, p = 0.01). Endothelial function was significantly preserved in the HFD + Ex group (p<0.05). Serum interleukin-6 and macrophage chemoat-tractant protein-1 levels were significantly lower and those of adiponectin were significantly higher in the HFD + Ex group than in the HFD group (p< 0.05). Conclusions: These results suggest that Ex ameliorates the progression of endothelial dysfunction and atherosclerotic lesion formation through anti-inflammatory effects, despite continued consumption of HFD.

Original languageEnglish
Pages (from-to)1226-1236
Number of pages11
JournalJournal of atherosclerosis and thrombosis
Volume17
Issue number12
DOIs
Publication statusPublished - 2010

Keywords

  • Adiponectin
  • Apolipoprotein e-knockout mice
  • Atherosclerosis
  • Endothelial function
  • Voluntary exercise

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'Voluntary exercise ameliorates the progression of atherosclerotic lesion formation via anti-inflammatory effects in apolipoprotein e-deficient mice'. Together they form a unique fingerprint.

Cite this