Voltage-sensitive dye versus intrinsic signal optical imaging: Comparison of optically determined functional maps from rat barrel cortex

Ichiro Takashima, Riichi Kajiwara, Toshio Iijima

    Research output: Contribution to journalArticlepeer-review

    48 Citations (Scopus)

    Abstract

    Using intrinsic and voltage-sensitive dye optical imaging methods, somatosensory-evoked neural activity and the consequent metabolic activity were visualized in the barrel cortex at high temporal and spatial resolution. We compared maps of neural and metabolic activity from the perspective of spatial distribution in the cortex. There was good agreement between the two functional maps, if the extent of metabolic activity before a prominent increase in cerebral blood volume (CBV) was assessed. This result indicates that oxygen consumption occurs before CBV changes, in approximately the same cortical area as that in which the preceding neural activity was evoked. This also suggests that the intrinsic signal reflects subthreshold synaptic activity, as well as spiking activity, which is similar to the dye-related signals.

    Original languageEnglish
    Pages (from-to)2889-2894
    Number of pages6
    JournalNeuroReport
    Volume12
    Issue number13
    DOIs
    Publication statusPublished - 2001 Sep 17

    Keywords

    • Barrel cortex
    • Blood deoxyhemoglobin concentration
    • Cerebral blood volume
    • Intrinsic optical signal
    • Metabolic activity
    • Neural activity
    • Optical imaging
    • Voltage-sensitive dye

    ASJC Scopus subject areas

    • Neuroscience(all)

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