Vitisin A and cis-Vitisin A, Strongly Hepatotoxic Plant Oligostilbenes from Vitis coignetiae (Vitaceae)

Yoshiteru Oshima, Akio Kamijou, Hiroshi Moritani, Kei ichi Namao, Yasushi Ohizumi

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

The methanolic extract of one of the common Vitaceaeous plants, Vitis coignetiae, showed marked prevention against injuries of primary cultured rat liver cells induced by carbon tetrachloride and d-galactosamine. Activity-guided fractionation of the extract resulted in the isolation of not only an antihepatotoxic stilbene derivative, ϵ-viniferin, but also novel oligostilbenes, vitisin A and its stereoisomer cis-vitisin A as a mixture. The structures of the oligostilbenes have been determined on the basis of spectroscopic evidence, especially by 2D NMR methods such as HMBC spectra of degradative products. The mixture of vitisin A and cis-vitisin A was found to cause marked liver lesions in mice.

Original languageEnglish
Pages (from-to)850-853
Number of pages4
JournalJournal of Organic Chemistry
Volume58
Issue number4
DOIs
Publication statusPublished - 1993 Jan 1

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint Dive into the research topics of 'Vitisin A and cis-Vitisin A, Strongly Hepatotoxic Plant Oligostilbenes from Vitis coignetiae (Vitaceae)'. Together they form a unique fingerprint.

Cite this