Vitamin K can Suppress the Inflammation Induced by Lipopolysaccharide Administration

Hitoshi Shirakawa, Yusuke Ohsaki, Kazuyuki Hiwatashi, Yuji Furukawa, Michio Komai, Takeo Mizutani

Research output: Contribution to journalArticlepeer-review


Vitamin K (K) is essential for blood coagulation and bone metabolism in mammals. K acts as a cofactor in the posttranslational synthesis of g-carboxyglutamic acid from glutamic acid residues. In addition to liver and bone, K is found in brain, heart, kidney and gonadal tissue. However, the physiological role of K in these varied organs is not yet fully understood. It is likely that K has functions in addition to its role as a cofactor of protein g-glutamyl carboxylation. In this paper we used DNA microarray techniques to identify the effect of K status on gene expression in rat liver. Expression of genes involved in the acute inflammation response was enhanced in rats fed a K-deficient diet relative to control and K1-supplemented diet groups. Moreover, dietary supplementation with K1 suppressed inflammation induced by LPS administration. These results indicate that orally administrated K1 suppresses inflammation in the rat.

Original languageEnglish
Pages (from-to)284-285
Number of pages2
JournalJournal of Hard Tissue Biology
Issue number2
Publication statusPublished - 2005 Jan


  • DNA microarray
  • IL-6
  • Vitamin K
  • inflammation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry
  • Biomaterials
  • Orthopedics and Sports Medicine
  • Dentistry(all)
  • Cell Biology


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