Vitamin B12 improves cognitive disturbance in rodents fed a choline-deficient diet

H. Sasaki, Y. Matsuzaki, K. Meguro, Y. Ikarashi, Y. Maruyama, S. Yamaguchi, K. Sekizawa

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


The effect of vitamin B12 on learning disturbance was tested in rats. Rats were fed a choline-enriched, choline-deficient, and choline-deficient diet with vitamin B12. Concentrations of acetylcholine in the brain were significantly lower in rats fed a choline-deficient diet than rats fed a choline-enriched diet. Passive avoidance learning shows that rats on a choline-deficient diet showed significantly impaired learning compared to rats on a choline-enriched diet. However, there was no significant difference of acetylcholine in the brain or in the passive avoidance learning between rats fed a choline-enriched and a choline-deficient with vitamin B12 diet. We, therefore, suggest that vitamin B12 potentiates learning in an acetylcholine-deprived brain.

Original languageEnglish
Pages (from-to)635-639
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Issue number2
Publication statusPublished - 1992 Oct


  • Acetylcholine
  • Alzheimer's disease
  • Passive avoidance learning
  • Rat
  • Vitamin B

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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