Visual prognosis and vitreous cytokine levels after arteriovenous sheathotomy in branch retinal vein occlusion associated with macular oedema

Masahiko Shimura, Toru Nakazawa, Kanako Yasuda, Hiroshi Kunikata, Takashi Shiono, Kohji Nishida

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Purpose: To investigate the relationship between vitreous levels of cytokines, including interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF), and visual prognosis after pars plana vitrectomy (PPV) with arteriovenous sheathotomy in patients with branch retinal vein occlusion (BRVO) associated with macular oedema. Methods: We studied 60 patients with logMAR visual acuity (VA) scores of < 0.3 and visual impairment secondary to BRVO-associated macular oedema. All patients underwent PPV with arteriovenous sheathotomy. At the time of PPV, vitreous samples were collected from the operated eye and vitreous levels of VEGF and IL-6 were measured. Best corrected VA (BCVA) (using a logMAR chart) and foveal thickness (FT) (using optical coherence tomography) were monitored for up to 6months after PPV. Results: Both BCVA and FT significantly improved after PPV. According to multiple regression analysis, both the improvement in BCVA and decrease in FT were closely related to the vitreous level of IL-6 but not to that of VEGF. The vitreous level of VEGF was strongly correlated with duration of BRVO. Conclusions: Both improvement in BCVA and decrease in FT were observed after PPV in BRVO patients with macular oedema. Interestingly, these visual prognoses strongly correlate with the vitreous level of IL-6, whereas the duration of BRVO strongly correlates with the vitreous level of VEGF.

Original languageEnglish
Pages (from-to)377-384
Number of pages8
JournalActa Ophthalmologica
Volume86
Issue number4
DOIs
Publication statusPublished - 2008 Jun 1

Keywords

  • Branch retinal vein occlusion (BRVO)
  • Cytokine
  • Macular oedema
  • Visual prognosis
  • Vitrectomy

ASJC Scopus subject areas

  • Ophthalmology

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