Visual hallucinations and regional cerebral metabolism in dementia with lewy bodies (DLB)

Toru Imamura, Kazunari Ishii, Nobutsugu Hirono, Mamoru Hashimoto, Satoshi Tanimukai, Hiroaki Kazuai, Tokiji Hanihara, Masahiro Sasaki, Etsuro Mori

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

To investigate the neurobiological bases of visual hallucinations in dementia with Lewy bodies (DLB), regional cerebral glucose metabolism was compared among three patient groups; DLB with visual hallucinations, DLB without visual hallucinations and Alzheimer's disease (AD) without visual hallucinations. The regional metabolism was significantly lower in both DLB groups than in the AD group in the primary visual area and the posterior temporal, parietal and lateral occipital association areas. The hypometabolism in the right posterior temporal and parietal areas was significantly milder in DLB with visual hallucinations than in DLB without hallucinations. The hypometabolism in the primary visual cortex and the relatively preserved metabolism in the right temporoparietal association cortices may be associated with the occurrence of visual hallucinations in DLB patients.

Original languageEnglish
Pages (from-to)1903-1907
Number of pages5
JournalNeuroReport
Volume10
Issue number9
DOIs
Publication statusPublished - 1999 Jun 23

Keywords

  • Alzheimer's disease
  • Brain metabolism
  • Cerebral cortex
  • Dementia
  • Dementia with Lewy bodies
  • Hallucinations
  • Occipital lobe
  • Parietal lobe
  • Positron emission tomography
  • Temporal lobe

ASJC Scopus subject areas

  • Neuroscience(all)

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    Imamura, T., Ishii, K., Hirono, N., Hashimoto, M., Tanimukai, S., Kazuai, H., Hanihara, T., Sasaki, M., & Mori, E. (1999). Visual hallucinations and regional cerebral metabolism in dementia with lewy bodies (DLB). NeuroReport, 10(9), 1903-1907. https://doi.org/10.1097/00001756-199906230-00020