Visual function of a patient with advanced adrenoleukodystrophy: Comparison of luminance and color contrast sensitivities

Shinya Sakai, Kazumi Hirayama, Kaeko Ogura, Naoko Sakai, Mutsuko Sudoh, Naoya Murata, Syoichi Iwasaki

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

We assessed achromatic luminance and isoluminant chromatic contrast sensitivity functions of a 20-year-old male. He showed severe motor and intellectual disabilities after advanced adrenoleukodystrophy, which started at the age of 7. Optokinetic nystagmus (OKN) to drifting gratings was used to assess his contrast sensitivities. Although the achromatic luminance contrast sensitivities were lower over the entire range of spatial frequencies tested than those of the healthy adults, they were preserved to the level comparable to healthy 7-year-old children, except for the frequency of 1 and 4 cycles/degree. In contrast, both of the red-green and blue chromatic contrast sensitivities were remarkably lower in all frequency range compare to healthy children and adults. These results indicate that it is possible for even an advanced case of ALD to show residual visual capacity that was preserved to a remarkable extent.

Original languageEnglish
Pages (from-to)68-72
Number of pages5
JournalBrain and Development
Volume30
Issue number1
DOIs
Publication statusPublished - 2008 Jan

Keywords

  • Adrenoleukodystrophy
  • Color
  • Contrast sensitivity
  • Luminance
  • Residual visual capacity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

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