Visual event-related potential in mild dementia of the Alzheimer's type

Hidemitsu Saito, Hideki Yamazaki, Hiroo Matsuoka, Kazunori Matsumoto, Yohtaro Numachi, Sumiko Yoshida, Takashi Ueno, Mitsumoto Sato

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


Visual event-related potentials (ERP) and behavioral measures were recorded during a geometrical-figure discrimination task to examine sensory processing in 10 patients with mild dementia of the Alzheimer's type (DAT) and 10 age-matched controls. No difference existed between the groups in P1, N1, and P2 potentials, which reflects the early stage of sensory processing, as well as in NA potential, which reflects pattern recognition. The patients showed reduced amplitude of P3 potential, retarded reaction time, and increased behavioral errors compared to controls. These findings suggest that the patients with mild DAT were intact in early sensory processing including pattern recognition but were selectively compromised in higher-level processing, including integration of information and memory matching, which may influence behavioral deviation.

Original languageEnglish
Pages (from-to)365-371
Number of pages7
JournalPsychiatry and Clinical Neurosciences
Issue number4
Publication statusPublished - 2001


  • Dementia of the Alzheimer's type
  • Event-related potential
  • NA potential
  • P3 potential

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health


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