TY - JOUR
T1 - Visual analog scale as a predictor of GINA-defined asthma control. The SACRA study in Japan
AU - Ohta, Ken
AU - Jean Bousquet, Philippe
AU - Akiyama, Kazuo
AU - Adachi, Mitsuru
AU - Ichinose, Masakazu
AU - Ebisawa, Motohiro
AU - Tamura, Gen
AU - Nagai, Atsushi
AU - Nishima, Sankei
AU - Fukuda, Takeshi
AU - Morikawa, Akihiro
AU - Okamoto, Yoshitaka
AU - Kohno, Yoichi
AU - Saito, Hirohisa
AU - Takenaka, Hiroshi
AU - Grouse, Larry
AU - Bousquet, Jean
N1 - Funding Information:
Ken Ohta has received honorarium for boards, scientific expertize, lectures from AstraZeneca, GSK, Kyorin, MSD, Novartis. Philippe Jean Bousquet has received honorarium for lectures and scientific expertize from Stallerge’nes Actelion. Jean Bousquet has received honorarium for boards, scientific expertize, lectures from Stallerge’nes Actelion, Almirall, AstraZeneca, Chiesi, GSK, Merck, Novartis, OM pharma, Sanofi Aventis, Teva, Uriach. Takeshi Fukuda has received research grants from Astra Zeneca, MSD, GSK. Sankei Nishima has received honorarium for scientific expertize from Teijin Pharma. Yoshitaka Okamoto has received honorarium for scientific expertize and research grants from Kyorin, Kyowa-Kirin, MSD, Shionogi, GSK. The following authors have no conflict to declare: Kazuo Akiyama, Mitsuru Adachi, Lawrence Grouse, Masakazu Ichinose, Motohiro Ebisawa, Gen Tamura, Atsushi Nagai, Akihiro Morikawa, Yoichi Kohno, Hirohisa Saito, and Hiroshi Takenaka.
PY - 2013/6
Y1 - 2013/6
N2 - Objective. The assessment of asthma control is pivotal to treatment decisions. A questionnaire that assesses the Global Initiative for Asthma (GINA)-defined control requires four questions. A visual analog scale (VAS) to evaluate asthma control can be simply marked, but its correlation with GINA-defined control has been insufficiently evaluated. The purpose of this study is to evaluate whether VAS levels can predict GINA-defined asthma control with particular emphasis on the distinctions between "partly controlled" and "uncontrolled" and between "partly controlled" and "controlled" asthma, Methods. A cross-sectional multicenter study was carried out throughout Japan (SACRA) from March to August 2009 among patients with a diagnosis and treatment of asthma. Asthma control was studied using the GINA questionnaire and a VAS measurement of asthma severity. Pulmonary function testing was not carried out, Results. 1910 physicians enrolled 29,518 patients with asthma. 15,051 (51.0%) questionnaires were administered by physicians; patients filled out 14,076 (47.7%) questionnaires themselves. 28,225 (95.6%) of the patients were evaluable. VAS measurement of asthma symptoms was useful in predicting levels of GINA-defined control categories (the area under the receiver operating characteristic curve ranging from 0.704 to 0.837). Patients with "controlled," "partly controlled," and "uncontrolled" asthma were discriminated by VAS levels (1.50, 4.79, and 7.19). Similar results have been obtained with self- and physician-administered questionnaires showing the validity of results. Conclusion. Measurement of VAS levels is able to discriminate between patients with "controlled," "partly controlled," and "uncontrolled" asthma. The VAS score could be a simple guide in clinical situations requiring daily or regular evaluation of asthma control.
AB - Objective. The assessment of asthma control is pivotal to treatment decisions. A questionnaire that assesses the Global Initiative for Asthma (GINA)-defined control requires four questions. A visual analog scale (VAS) to evaluate asthma control can be simply marked, but its correlation with GINA-defined control has been insufficiently evaluated. The purpose of this study is to evaluate whether VAS levels can predict GINA-defined asthma control with particular emphasis on the distinctions between "partly controlled" and "uncontrolled" and between "partly controlled" and "controlled" asthma, Methods. A cross-sectional multicenter study was carried out throughout Japan (SACRA) from March to August 2009 among patients with a diagnosis and treatment of asthma. Asthma control was studied using the GINA questionnaire and a VAS measurement of asthma severity. Pulmonary function testing was not carried out, Results. 1910 physicians enrolled 29,518 patients with asthma. 15,051 (51.0%) questionnaires were administered by physicians; patients filled out 14,076 (47.7%) questionnaires themselves. 28,225 (95.6%) of the patients were evaluable. VAS measurement of asthma symptoms was useful in predicting levels of GINA-defined control categories (the area under the receiver operating characteristic curve ranging from 0.704 to 0.837). Patients with "controlled," "partly controlled," and "uncontrolled" asthma were discriminated by VAS levels (1.50, 4.79, and 7.19). Similar results have been obtained with self- and physician-administered questionnaires showing the validity of results. Conclusion. Measurement of VAS levels is able to discriminate between patients with "controlled," "partly controlled," and "uncontrolled" asthma. The VAS score could be a simple guide in clinical situations requiring daily or regular evaluation of asthma control.
KW - ARIA
KW - AUC
KW - Co-morbidity
KW - ROC
KW - Rhinitis
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U2 - 10.3109/02770903.2013.786726
DO - 10.3109/02770903.2013.786726
M3 - Article
C2 - 23506422
AN - SCOPUS:84878149462
VL - 50
SP - 514
EP - 521
JO - Journal of Asthma
JF - Journal of Asthma
SN - 0277-0903
IS - 5
ER -