Viscoelastic imaging using acoustic impedance microscope and its application to biological tissue

Naohiro Hozumi, Shota Kajima, Agus Indra Gunawan, Sachiko Yoshida, Kazuto Kobayashi, Yoshifumi Saijo, Seiji Yamamoto

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A new method of viscoelastic micro-imaging for soft biological tissue has been proposed. A target is placed on a plastic substrate. Ultrasonic beam, which is focused on the target, is transmitted and the reflection is received by the same transducer. Shear wave can be produced as the result of oblique incidence to the substrate. By adjusting the distance between the transducer and target either pressure or shear wave can be focused onto the target. It is easy to identify and extract each mode of the reflection in time domain, because pulse wave is transmitted. The reflection is once interpreted into characteristic acoustic impedance of the target, making use of the acoustic parameters of the substrate and reference material. Precise sound field analysis is required to create the calibration curve, because the incidence is not totally perpendicular to the substrate. The acoustic impedance for pressure wave is directly converted into bulk modulus. The (apparent) acoustic impedance for shear wave is interpreted into shear modulus and viscosity, making use of its frequency dependency. A 2-D profile of bulk modulus, shear modulus and viscosity may be obtained by mechanically scanning the transducer. As for a preliminary experiment, cancerous liver of rat was observed using acoustic impedance microscope with a frequency range of roughly 30-100 MHz. Viscosity profile showed a good correlation with stained image by optical microscope.

Original languageEnglish
Title of host publication2015 IEEE International Ultrasonics Symposium, IUS 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781479981823
DOIs
Publication statusPublished - 2015 Nov 13
EventIEEE International Ultrasonics Symposium, IUS 2015 - Taipei, Taiwan, Province of China
Duration: 2015 Oct 212015 Oct 24

Publication series

Name2015 IEEE International Ultrasonics Symposium, IUS 2015

Other

OtherIEEE International Ultrasonics Symposium, IUS 2015
CountryTaiwan, Province of China
CityTaipei
Period15/10/2115/10/24

Keywords

  • acoustic impedance microscopy
  • biological soft tissue
  • viscoelastic micro-imaging

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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    Hozumi, N., Kajima, S., Gunawan, A. I., Yoshida, S., Kobayashi, K., Saijo, Y., & Yamamoto, S. (2015). Viscoelastic imaging using acoustic impedance microscope and its application to biological tissue. In 2015 IEEE International Ultrasonics Symposium, IUS 2015 [7329250] (2015 IEEE International Ultrasonics Symposium, IUS 2015). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ULTSYM.2015.0172