Very-long-distance correlations in proteins revealed by solid-state NMR spectroscopy

Bingwen Hu; Julien Trébosc; Oliver Lafon; Qun Chen; Yuichi Masuda; K. Takegoshi; Jean Paul Amoureux

doi:10.1002/cphc.201200548

Very-long-distance correlations in proteins revealed by solid-state NMR spectroscopy

Bingwen Hu, Julien Trébosc, Oliver Lafon, Qun Chen, Yuichi Masuda, K. Takegoshi, Jean Paul Amoureux

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

I still see you: A new pulse sequence, SHA+, little sensitive to dipolar truncation, allows direct or relayed polarization transfer between ¹³C atoms, distant by 3.5-9.6 Å, in amyloid fibrils (see picture). SHA+ can also be used in a broadband way with the weak rf-condition of v₁v_R≈0.2-0.3 which permits the investigation of temperature-sensitive biological systems.

Original language	English
Pages (from-to)	3585-3588
Number of pages	4
Journal	ChemPhysChem
Volume	13
Issue number	16
DOIs	https://doi.org/10.1002/cphc.201200548
Publication status	Published - 2012 Nov 12

Keywords

Amyloid beta-peptides
NMR spectroscopy
magic-angle spinning
polarization transfer
protein structures

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Physical and Theoretical Chemistry

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10.1002/cphc.201200548

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AU - Hu, Bingwen

AU - Trébosc, Julien

AU - Lafon, Oliver

AU - Chen, Qun

AU - Masuda, Yuichi

AU - Takegoshi, K.

AU - Amoureux, Jean Paul

PY - 2012/11/12

Y1 - 2012/11/12

N2 - I still see you: A new pulse sequence, SHA+, little sensitive to dipolar truncation, allows direct or relayed polarization transfer between 13C atoms, distant by 3.5-9.6 Å, in amyloid fibrils (see picture). SHA+ can also be used in a broadband way with the weak rf-condition of v1vR≈0.2-0.3 which permits the investigation of temperature-sensitive biological systems.

AB - I still see you: A new pulse sequence, SHA+, little sensitive to dipolar truncation, allows direct or relayed polarization transfer between 13C atoms, distant by 3.5-9.6 Å, in amyloid fibrils (see picture). SHA+ can also be used in a broadband way with the weak rf-condition of v1vR≈0.2-0.3 which permits the investigation of temperature-sensitive biological systems.

KW - Amyloid beta-peptides

KW - NMR spectroscopy

KW - magic-angle spinning

KW - polarization transfer

KW - protein structures

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Very-long-distance correlations in proteins revealed by solid-state NMR spectroscopy

Abstract

Keywords

ASJC Scopus subject areas

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