Ventricular fibrillation mechanisms and cardiac restitutions: An investigation by simulation study on whole-heart model

Yi Zheng, Daming Wei, Xin Zhu, Wenxi Chen, Koji Fukuda, Hiroaki Shimokawa

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Background: The action potential duration (APD) and the conduction velocity (CV) restitution have been reported to be important in the maintenance and conversion of ventricular fibrillation (VF), whose mechanisms remain poorly understood. Multiple-wavelet and/or mother-rotor have been regarded as the main VF mechanisms, and APD restitution (APDR) and CV restitution (CVR) properties are involved in the mutual conversion or transition between VF and ventricular tachycardia (VT). Methods and results: The effects of APDR (both its slope and heterogeneity) and CVR on VF organization and conversion were examined using a "rule-based" whole-heart model. The results showed that different organizations of simulated VF were manifestations of different restitution configurations. Multiple-wavelet and mother-rotor VF mechanisms could recur in models with steep and heterogeneous APDR, respectively. Suppressing the excitability either decreased or increased the VF complexity under the steep or shallow APDR, respectively. The multiple-wavelet VF changed into a VT in response to a flattening of the APDR, and the VT degenerated into a mother-rotor VF due to the APDR heterogeneity. Conclusions: Our results suggest that the mechanisms of VF are tightly related to cardiac restitution properties. From a viewpoint of the "rule-based" whole-heart model, our work supports the hypothesis that the synergy between APDR and CVR contributes to transitions between multiple-wavelet and mother-rotor mechanisms in the VF.

Original languageEnglish
Pages (from-to)261-268
Number of pages8
JournalComputers in Biology and Medicine
Publication statusPublished - 2015 Aug 1


  • Action potential duration restitution
  • Computer simulation
  • Conduction velocity restitution
  • Ventricular fibrillation
  • Whole-heart model

ASJC Scopus subject areas

  • Computer Science Applications
  • Health Informatics


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