Vasohibin prevents arterial neointimal formation through angiogenesis inhibition

Hiroshi Yamashita, Mayumi Abe, Kazuhide Watanabe, Kazue Shimizu, Takuya Moriya, Akira Sato, Susumu Satomi, Hideki Ohta, Hikaru Sonoda, Yasufumi Sato

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

Vasohibin is a VEGF-inducible angiogenesis inhibitor in vascular endothelium. Here we examined the presence of vasohibin in human arterial wall, and found it in endothelium of adventitial microvessels in atherosclerotic lesion. Adventitial angiogenesis is involved in the progression of neointimal formation. Even in the presence of endogenous angiogenesis inhibitors, pathological angiogenesis persists. However, the supplementation of exogenous angiogenesis inhibitors can prevent pathological angiogenesis. We evaluated the potential role of vasohibin in neointimal formation. Adenovirus-mediated human vasohibin gene transfer in mouse liver resulted in the release of vasohibin in plasma and exhibited anti-angiogenic effects at remote sites. This gene transfer inhibited adventitial angiogenesis, macrophage infiltration, and neointimal formation after cuff placement on mouse femoral artery. Vasohibin exhibited no direct effect on migration and proliferation of smooth muscle cells. Thus, vasohibin has an activity to prevent neointimal formation by inhibiting adventitial angiogenesis.

Original languageEnglish
Pages (from-to)919-925
Number of pages7
JournalBiochemical and biophysical research communications
Volume345
Issue number3
DOIs
Publication statusPublished - 2006 Jul 7

Keywords

  • Angiogenesis inhibitor
  • Atherosclerosis
  • Neointimal formation
  • Vasohibin

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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