Vasoactive Intestinal Peptide (VIP) - Induced pulmonary vasodilation mediated by EDRF/NO in isolated perfused rat lungs

S. Iwabuchi, S. Ono, J. Funata, Y. Hoshikawa, S. Ueda, Y. Ashino, T. Tanita, S. Fujimura, K. Koike

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We studied the effects of Vasoactive Intestinal Peptide (VIP) on the pulmonary circulation in isolated perfused rat lungs. VIP caused pulmonary vasodilation in a dose-dependent manner. This effect was inhibited by pretreatment with L-Nω nitro-arginine (L-NNA), a competitive inhibitor of endothelium-derived relaxing factor (EDRF/NO), but not by meclofenamate, a cyclooxygenase inhibitor. Addition of L-arginine, a substrate of EDRF/NO, after treatment with L-NNA reversed VIP-induced pulmonary vasodilation. These results indicate that VIP causes pulmonary vasodilation, and they suggest a role for EDRF/NO in VIP-induced pulmonary vasodilation in isolated rat lungs.

Original languageEnglish
Pages (from-to)262-267
Number of pages6
JournalJapanese Journal of Thoracic Diseases
Volume33
Issue number3
Publication statusPublished - 1995 Jan 1

Keywords

  • Endothelium-derived relaxing factor
  • Isolated perfused lung
  • L- Nω-nitro-arginine
  • Rat
  • Vasoactive Intestinal Peptide

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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