TY - JOUR
T1 - Vasculitis-susceptible genes in mice with a deficit in Fas-mediated apoptosis
AU - Nose, Masato
AU - Terada, Miho
AU - Nishihara, Miyuki
AU - Kamogawa, Junji
AU - Miyazaki, Tatsuhiko
AU - Mori, Shiro
AU - Nishimura, Masahiko
AU - Wang, Yun
AU - Kamoto, Toshiyuki
AU - Hiai, Hiroshi
PY - 1998/10/1
Y1 - 1998/10/1
N2 - Autoimmune diseases show complex pathological manifestations, which frequently involve systemic vasculitis. This complication is understood to be a manifestation of advanced disease, or to represent distinct entities, restricted by genetic and/or environmental factors. An MRL/Mp strain of mice beating the Fas deletion mutant gene, lpr (MRL/lpr), spontaneously develop systemic vasculitis coincidentally with glomerulonephritis, arthritis and sialoadenitis, but a C3H/HeJ-lpr/lpr (C3H/lpr) strain does not. Thus, this is a suitable model for analyzing the genetic basis of vasculitis in autoimmune diseases. To genetically dissect these complex pathological manifestations, a linkage analysis of each lesion with polymorphic microsatellite markers was performed by using MRL/lprX(MRL/lprX C3H/lpr)F1 backcross mice. Vasculitis- susceptible gene loci were mapped on chromosomes 3 and 4, which were not associated with glomerulonephritis, arthritis and sialoadenitis. These results indicate that systemic vasculitis in MRL/lpr mice may be under the control of host genes which are different from those for other autoimmune diseases.
AB - Autoimmune diseases show complex pathological manifestations, which frequently involve systemic vasculitis. This complication is understood to be a manifestation of advanced disease, or to represent distinct entities, restricted by genetic and/or environmental factors. An MRL/Mp strain of mice beating the Fas deletion mutant gene, lpr (MRL/lpr), spontaneously develop systemic vasculitis coincidentally with glomerulonephritis, arthritis and sialoadenitis, but a C3H/HeJ-lpr/lpr (C3H/lpr) strain does not. Thus, this is a suitable model for analyzing the genetic basis of vasculitis in autoimmune diseases. To genetically dissect these complex pathological manifestations, a linkage analysis of each lesion with polymorphic microsatellite markers was performed by using MRL/lprX(MRL/lprX C3H/lpr)F1 backcross mice. Vasculitis- susceptible gene loci were mapped on chromosomes 3 and 4, which were not associated with glomerulonephritis, arthritis and sialoadenitis. These results indicate that systemic vasculitis in MRL/lpr mice may be under the control of host genes which are different from those for other autoimmune diseases.
KW - Apoptosis
KW - Arteritis
KW - Arthritis
KW - Disease-susceptible gene
KW - Fas
KW - Fas ligand
KW - Glomerulonephritis
KW - MRL mice
KW - Sialoadenitis
UR - http://www.scopus.com/inward/record.url?scp=0032193703&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032193703&partnerID=8YFLogxK
U2 - 10.1016/S0167-5273(98)00146-6
DO - 10.1016/S0167-5273(98)00146-6
M3 - Article
C2 - 9951801
AN - SCOPUS:0032193703
VL - 66
SP - S37-S41+S43
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - SUPPL. 1
ER -