Vascular Remodeling After Cerebral Ischemia

Y. Nishijima, Y. Akamatsu, K. Masamoto, J. Liu

Research output: Chapter in Book/Report/Conference proceedingChapter


The blood vessels in the adult brain respond to ischemia and hypoxia by remodeling the existing vessels and forming new vessels, a process known as neovascularization. Based on the differences in timing of occurrence and cellular/molecular mechanisms involved, neovascularization can be viewed as three distinct processes, i.e., angiogenesis, vasculogenesis, and arteriogenesis. Despite the differential contribution in neuroprotection and neurorestoration from each, neovascularization is positively correlated with clinical outcome, suggesting that it is a viable target for stroke intervention. In this review we discuss these endogenous revascularization processes, the unique and shared underlying cellular/molecular mechanisms, as well as current known therapies and their limitations in vascular risk factors.

Original languageEnglish
Title of host publicationPrimer on Cerebrovascular Diseases
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages6
ISBN (Print)9780128030585
Publication statusPublished - 2017 Mar 7


  • Anastomosis
  • Angiogenesis
  • Arteriogenesis
  • Collateral flow
  • Endothelial progenitor cells
  • Hypoxia
  • Shear stress
  • Vasculogenesis

ASJC Scopus subject areas

  • Neuroscience(all)


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