Vascular lesions in mixed dementia, vascular dementia, and Alzheimer disease with cerebrovascular disease: The Kurihara Project

Kenichi Meguro, Naofumi Tanaka, Masahiro Nakatsuka, Kei Nakamura, Masayuki Satoh

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

The concept and diagnosis for mixed dementia is not simple, since it is difficult to identify the type and regions of cerebrovascular disease (CVD) responsible for causing dementia. An investigation is needed to confirm the presence of mixed dementia, those who met the criteria for Alzheimer's disease (AD) and those for vascular dementia (VaD). According to the community-based stroke, dementia, and bed-confinement prevention in Kurihara, northern Japan (Kurihara Project), the prevalence of dementia and dementing diseases was surveyed in 2008-2010. Five hundred and ninety people finally agreed to participate (47.0%), and 73 (12.4%) people were diagnosed with dementia according to the DSM-IV. Using MRI, intensive evaluations on CVDs were performed for the 49 dementia patients associated with CVDs (mixed dementia, VaD, and AD with CVD). For the mixed dementia group, all had left subcortical strategic CVDs. These included the caudate head and thalamus. For the VaD group, all patients had at least cortical CVDs or subcortical strategic CVDs. The AD with CVD group had non-strategic CVDs in cortical, subcortical, or other areas in 5 or 6 patients each. Two extreme concepts regarding CVD and dementia are possible. One is that there is no concept for mixed dementia or VaD. An alternative is that the vascular factor should be considered as primary. Our data showed an importance of cortical and subcortical strategic areas, the latter included thalamus and caudate head.

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalJournal of the neurological sciences
Volume322
Issue number1-2
DOIs
Publication statusPublished - 2012 Nov 15

Keywords

  • Alzheimer's disease
  • MRI
  • Mixed dementia
  • Vascular dementia
  • Vascular lesion

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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