Vascular function

In summary, the interactions among ECs, VSMCs, adventitial tissues, and inflammatory cells regulate vascular functions and diseases. As reviewed in this highlights, recent publications in ATVB have significantly contributed to our understanding on the roles of each vascular cell component for vascular functions in health and disease. These studies have demonstrated the novel mechanistic roles of secreted factors, as well as intracellular signaling for endothelial homeostasis, VSMC proliferation, and inflammatory cell migration. Indeed, we are getting closer to the understanding of fundamental vascular functions and causative cell signaling pathways, all of which should be useful for the development of novel therapeutic strategies in cardiovascular medicine.