TY - JOUR
T1 - Vascular function
AU - Shimokawa, Hiroaki
AU - Satoh, Kimio
N1 - Publisher Copyright:
© 2014 American Heart Association, Inc.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - In summary, the interactions among ECs, VSMCs, adventitial tissues, and inflammatory cells regulate vascular functions and diseases. As reviewed in this highlights, recent publications in ATVB have significantly contributed to our understanding on the roles of each vascular cell component for vascular functions in health and disease. These studies have demonstrated the novel mechanistic roles of secreted factors, as well as intracellular signaling for endothelial homeostasis, VSMC proliferation, and inflammatory cell migration. Indeed, we are getting closer to the understanding of fundamental vascular functions and causative cell signaling pathways, all of which should be useful for the development of novel therapeutic strategies in cardiovascular medicine.
AB - In summary, the interactions among ECs, VSMCs, adventitial tissues, and inflammatory cells regulate vascular functions and diseases. As reviewed in this highlights, recent publications in ATVB have significantly contributed to our understanding on the roles of each vascular cell component for vascular functions in health and disease. These studies have demonstrated the novel mechanistic roles of secreted factors, as well as intracellular signaling for endothelial homeostasis, VSMC proliferation, and inflammatory cell migration. Indeed, we are getting closer to the understanding of fundamental vascular functions and causative cell signaling pathways, all of which should be useful for the development of novel therapeutic strategies in cardiovascular medicine.
KW - Endothelial cells
KW - Muscle, smooth, vascular
UR - http://www.scopus.com/inward/record.url?scp=84911903616&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84911903616&partnerID=8YFLogxK
U2 - 10.1161/ATVBAHA.114.304119
DO - 10.1161/ATVBAHA.114.304119
M3 - Review article
C2 - 25147337
AN - SCOPUS:84911903616
VL - 34
SP - 2359
EP - 2362
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
SN - 1079-5642
IS - 11
ER -