TY - JOUR
T1 - Vascular-derived reactive oxygen species for homeostasis and diseases
AU - Satoh, Kimio
AU - Berk, Bradford C.
AU - Shimokawa, Hiroaki
N1 - Funding Information:
This work was supported by Grants-in-Aid from the Japanese Ministry of Education, Culture, Sports, Science and Technology , Tokyo, Japan, and the Grants-in-Aid for Scientific Research from the Ministry of Health, Labour, and Welfare , Tokyo, Japan. We are grateful to members of the Aab Cardiovascular Research Institute at the University of Rochester School of Medicine for useful suggestions, especially work performed by Duan-Fang Liao, Zheng-Gen Jin, Jun Suzuki, Tetsuya Matoba, and Patrizia Nigro.
PY - 2011/8/1
Y1 - 2011/8/1
N2 - Numerous basic and clinical studies have clearly identified that reactive oxygen species (ROS, i.e., H 2O 2, O2-, and OH) has a major role in the development of cardiovascular diseases. However, we still have no strong therapeutic strategy for clinical benefits of antioxidant administration. One potential reason for those could be a crucial role of ROS for intracellular signaling pathways that is important for vascular functions in a very low concentration. ROS contributes to the physiology and pathology of vasculature, but precise molecular regulations remain elusive. The mechanism how excessive ROS (oxidative stress) deteriorate vascular function and promote vascular diseases has not been clearly elucidated. Cyclophilin A (CyPA) has been studied as a multifunctional protein that is upregulated in a variety of inflammatory conditions, such as rheumatoid arthritis, autoimmune disease, and cancer. CyPA has been classified as an immunophilins and has a variety of intracellular functions including intracellular signaling, protein trafficking, and the regulating other proteins. Besides intracellular functions, we revealed that CyPA is a secreted molecule that has a pathological role in the cardiovascular system. CyPA has emerged as a potential biomarker and mediator of cardiovascular disease.
AB - Numerous basic and clinical studies have clearly identified that reactive oxygen species (ROS, i.e., H 2O 2, O2-, and OH) has a major role in the development of cardiovascular diseases. However, we still have no strong therapeutic strategy for clinical benefits of antioxidant administration. One potential reason for those could be a crucial role of ROS for intracellular signaling pathways that is important for vascular functions in a very low concentration. ROS contributes to the physiology and pathology of vasculature, but precise molecular regulations remain elusive. The mechanism how excessive ROS (oxidative stress) deteriorate vascular function and promote vascular diseases has not been clearly elucidated. Cyclophilin A (CyPA) has been studied as a multifunctional protein that is upregulated in a variety of inflammatory conditions, such as rheumatoid arthritis, autoimmune disease, and cancer. CyPA has been classified as an immunophilins and has a variety of intracellular functions including intracellular signaling, protein trafficking, and the regulating other proteins. Besides intracellular functions, we revealed that CyPA is a secreted molecule that has a pathological role in the cardiovascular system. CyPA has emerged as a potential biomarker and mediator of cardiovascular disease.
KW - Reactive oxygen species
KW - Remodeling
KW - Vasculature
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U2 - 10.1016/j.niox.2011.04.005
DO - 10.1016/j.niox.2011.04.005
M3 - Article
C2 - 21565278
AN - SCOPUS:80051548139
VL - 25
SP - 211
EP - 215
JO - Nitric Oxide - Biology and Chemistry
JF - Nitric Oxide - Biology and Chemistry
SN - 1089-8603
IS - 2
ER -