TY - JOUR
T1 - Various meteorological conditions exhibit both immediate and delayed influences on the risk of stroke events
T2 - The HEWS-stroke study
AU - Hiroshima 'Emergency and Weather' Study-stroke collaborators
AU - Mukai, Tomoya
AU - Hosomi, Naohisa
AU - Tsunematsu, Miwako
AU - Sueda, Yoshimasa
AU - Shimoe, Yutaka
AU - Ohshita, Tomohiko
AU - Torii, Tsuyoshi
AU - Aoki, Shiro
AU - Nezu, Tomohisa
AU - Maruyama, Hirofumi
AU - Kakehashi, Masayuki
AU - Matsumoto, Masayasu
AU - Haji, Shotaro
AU - Hayashi, Yuki
AU - Kono, Michihiro
AU - Yamashita, Hiroshi
AU - Agari, Dai
AU - Kohriyama, Tatsuo
AU - Muguruma, Kazuki
AU - Nomura, Eiichi
AU - Toji, Hiromasa
AU - Yamawaki, Takemori
AU - Dohi, Eisuke
AU - Fujii, Hiroki
AU - Ishihara, Aiko
AU - Ishihara-Kawase, Kayoko
AU - Kinoshita, Naoto
AU - Kitamura, Juri
AU - Kono, Tomoyuki
AU - Kotozaki, Teppei
AU - Kubo, Satoshi
AU - Kurashige, Takeshi
AU - Matsushima, Hayato
AU - Miyachi, Takafumi
AU - Nagano, Yoshito
AU - Nakamura, Takeshi
AU - Nishikawa, Tomokazu
AU - Ochi, Kazuhide
AU - Ohtsuki, Toshiho
AU - Ota, Yoko
AU - Segawa, Akiko
AU - Shimomura, Ryo
AU - Shinozaki, Yukari
AU - Shishido, Takeo
AU - Sugiura, Tomohito
AU - Takahashi, Tetsuya
AU - Takeda, Ikuko
AU - Tanaka, Hitomi
AU - Tanaka, Hitomi
AU - Ueno, Hiroki
N1 - Publisher Copyright:
© 2017 Mukai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - We hypothesized that meteorological conditions on the onset day and conditions on the former days may play important roles in the modulation of physical conditions. Associations of meteorological factors and their changes in former days with stroke onset are of interest. We conducted a multicenter retrospective study to evaluate the frequency of stroke events and their interaction with meteorological conditions and their daily changes. Acute stroke patients (n = 3935, 73.5±12.4 years, 1610 females) who were admitted to 7 stroke hospitals in three restricted areas were enrolled in this study. Poisson regression models involving time-lag variables was used to compare daily rates of stroke events with mean thermohydrological index (THI), atmospheric pressure, and their daily changes. We divided onset days into quintiles based on the THI, atmospheric pressure, and their daily changes for the last 7 days. The frequencies of ischemic stroke significantly increased when THI varied either cooler or warmer from a previous day (extremely cooler, risk ratio (RR) 1.19, 95% confidence interval (CI) 1.05 to 1.34; extremely warmer, RR 1.16, 95% CI 1.03 to 1.31; r2 = 0.001 for the best regression, p = 0.001). Intracerebral hemorrhage frequencies significantly decreased on high-THI days (extremely high, RR 0.72, 95% CI 0.54 to 0.95; r2 = 0.013 for the best regression, p<0.001) and increased in high atmospheric pressure days (high, RR 1.31, 95% CI 1.04 to 1.65; r2 = 0.009 for the best regression, p<0.001). Additionally, even after adjusting for the THI on the onset day and its changes for the other days, intracerebral hemorrhage increased when THI got extremely cooler in 4 days prior (RR 1.33, 95% CI 1.03 to 1.71, r2 = 0.006 for the best regression, p<0.001). Various meteorological conditions may exhibit influences on stroke onset. And, when temperature cooled, there may be a possibility to show delayed influence on the frequency of intracerebral hemorrhage 4 days later.
AB - We hypothesized that meteorological conditions on the onset day and conditions on the former days may play important roles in the modulation of physical conditions. Associations of meteorological factors and their changes in former days with stroke onset are of interest. We conducted a multicenter retrospective study to evaluate the frequency of stroke events and their interaction with meteorological conditions and their daily changes. Acute stroke patients (n = 3935, 73.5±12.4 years, 1610 females) who were admitted to 7 stroke hospitals in three restricted areas were enrolled in this study. Poisson regression models involving time-lag variables was used to compare daily rates of stroke events with mean thermohydrological index (THI), atmospheric pressure, and their daily changes. We divided onset days into quintiles based on the THI, atmospheric pressure, and their daily changes for the last 7 days. The frequencies of ischemic stroke significantly increased when THI varied either cooler or warmer from a previous day (extremely cooler, risk ratio (RR) 1.19, 95% confidence interval (CI) 1.05 to 1.34; extremely warmer, RR 1.16, 95% CI 1.03 to 1.31; r2 = 0.001 for the best regression, p = 0.001). Intracerebral hemorrhage frequencies significantly decreased on high-THI days (extremely high, RR 0.72, 95% CI 0.54 to 0.95; r2 = 0.013 for the best regression, p<0.001) and increased in high atmospheric pressure days (high, RR 1.31, 95% CI 1.04 to 1.65; r2 = 0.009 for the best regression, p<0.001). Additionally, even after adjusting for the THI on the onset day and its changes for the other days, intracerebral hemorrhage increased when THI got extremely cooler in 4 days prior (RR 1.33, 95% CI 1.03 to 1.71, r2 = 0.006 for the best regression, p<0.001). Various meteorological conditions may exhibit influences on stroke onset. And, when temperature cooled, there may be a possibility to show delayed influence on the frequency of intracerebral hemorrhage 4 days later.
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U2 - 10.1371/journal.pone.0178223
DO - 10.1371/journal.pone.0178223
M3 - Article
C2 - 28575005
AN - SCOPUS:85020265411
VL - 12
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 6
M1 - e0178223
ER -