Variety of laminin exressions in murine neoplastic cell lines: Neuroblastoma NA cells produce only laminin B2 chain

K. Narumi, K. Satoh, M. Isemura, T. Sakai, T. Abe, S. Shindo, Toshiaki Kikuchi, K. Matsushima, M. Motomiya, T. Nukiwa

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

In the present study, we investigated the expression of laminin in three murine neoplastic cell lines; 3LL-SA (Lewis lung carcinoma), NA (neuroblastoma) and F9 (teratocarcinoma). Both Western and Northern blot analyses demonstrated that parietal endoderm-like F9 expressed three laminin chains A, B1 and B2. On the other hand, 3LL-SA cells synthesized two laminin chains B1 and B2, and NA cells only B2 chain. The analyses of the restriction fragment length polymorphism indicated that the genes for coding regions of all chains were present and grossly intact both in 3LL-SA and in NA just as in F9. These findings suggest that expression of laminin seems to be transcriptionally regulated in each neoplastic cell line specifically. Since these cell lines produce different forms of laminin, they can be used for investigation of the multifunctions of laminin molecule.

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalInternational journal of oncology
Volume4
Issue number1
Publication statusPublished - 1994 Jan 1

Keywords

  • laminin
  • lung carcinoma
  • murine
  • neuroblastoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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