Variation in the effect of particulate matter on pulmonary function in schoolchildren in Western Japan and its relation with sinterleukin-8

Masanari Watanabe, Hisashi Noma, Jun Kurai, Hiroyuki Sano, Hiroya Kitano, Rumiko Saito, Yutaka Kimura, Setsuya Aiba, Mitsuo Oshimura, Eiji Shimizu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

This study aimed to investigate the effects of particulate matter (PM) on pulmonary function in schoolchildren, as well as the relationships of these effects with interleukin-8. Morning peak expiratory flow (PEF) was measured daily in 399 children during April–May 2012, and in 384 of these children during March–May 2013. PEF’s association with the daily levels of suspended particulate matter (SPM) and PM < 2.5 μm (PM2.5) was estimated using a linear mixed model. Interleukin-8 promoter activity was assessed in THP-G8 cells stimulated by fallen PM collected at Tottori University Hospital during four periods (two in 2012 and two in 2013). An increase of 14.0 μg/m3 in SPM led to PEF changes of −2.16 L/min in 2012 and −0.81 L/min in 2013, respectively. An increment of 10.7 μg/m3 in PM2.5 was associated with PEF changes of −2.58 L/min in 2012 and −0.55 L/min in 2013, respectively. These associations were only significant in 2012. Interleukin-8 promoter activity was significantly higher in both periods of 2012 than in 2013. There was a significant association between pulmonary function in schoolchildren and daily levels of SPM and PM2.5, but this association may differ depending on the PM’s ability to elicit interleukin-8 production.

Original languageEnglish
Pages (from-to)14229-14243
Number of pages15
JournalInternational journal of environmental research and public health
Volume12
Issue number11
DOIs
Publication statusPublished - 2015 Nov 9

Keywords

  • Interlukin-8
  • PM
  • Peak expiratory flow
  • Schoolchildren
  • Suspended particle matter

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Fingerprint Dive into the research topics of 'Variation in the effect of particulate matter on pulmonary function in schoolchildren in Western Japan and its relation with sinterleukin-8'. Together they form a unique fingerprint.

  • Cite this