Variable product specificity of solanesyl pyrophosphate synthetase

Hiroshi Fujii, Hiroshi Sagami, Tanetoshi Koyama, Kyozo Ogura, Shuichi Seto, Tsuneo Baba, Charles M. Allen

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


The distribution of polyprenyl pyrophosphates synthesized by the action of solanesyl pyrophosphate synthetase from Micrococcus luteus is dramatically changed depending on the Mg++ concentration. When the metal ion concentration is higher than 5 mM, octaprenyl and solanesyl (nonaprenyl) pyrophosphate are synthesized predominantly. On the other hand, when the metal ion level is lower than 0.5 mM, a variety of polyprenyl pyrophosphates ranging in carbon chain length from C15 to C40 are formed. Heptaprenyl pyrophosphate is the longest of the products formed at 0.1 mM of Mg++.

Original languageEnglish
Pages (from-to)1648-1653
Number of pages6
JournalTopics in Catalysis
Issue number4
Publication statusPublished - 1980


  • HPLC
  • PP
  • high pressure liquid chromatography
  • pyrophosphate

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Biophysics
  • Molecular Biology


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