Value of prostate-specific antigen measurements in predicting lymph node involvement in prostatic cancer

Y. Arai, T. Yoshiki, H. Yamabe, O. Yoshida

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The preoperative serum levels of prostate-specific antigen (PA) were determined in 35 consecutive patients who had clinically localized prostatic cancer and underwent bilateral staging pelvic lymphadenectomy. When 10.0 ng/ml of PA was used as the cutoff value for lymph node staging the specificity of an elevated PA level in revealing lymph node involvement was 77% with a sensitivity of 85% and an accuracy of 80%. Only 1 of 18 (6%) patients with negative PA levels (below 10 ng/ml) and a preoperative Gleason score 2-7 tumor had metastatic lymph node disease. Among the 17 patients with positive PA levels (above 10 ng/ml) or a Gleason score 8-10 tumor, 12 (71%) had lymph node involvement. The preoperative PA level and the extent of local tumor invasion correlated strongly with each other. Our study suggests that the PA level could be a simple and objective parameter with which to predict metastatic lymph node disease if used in conjunction with the Gleason histological grade.

Original languageEnglish
Pages (from-to)356-360
Number of pages5
JournalUrologia Internationalis
Volume45
Issue number6
DOIs
Publication statusPublished - 1990 Jan 1

Keywords

  • Gleason grade
  • lymph node staging
  • prostate-specific antigen
  • prostatic cancer

ASJC Scopus subject areas

  • Urology

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