Validity of Shape as a Predictive Biomarker of Final Infarct Volume in Acute Ischemic Stroke

Carole Frindel, Anaïs Rouanet, Mathilde Giacalone, Tae Hee Cho, Leif Østergaard, Jens Fiehler, Salvador Pedraza, Jean Claude Baron, Marlène Wiart, Yves Berthezène, Norbert Nighoghossian, David Rousseau

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Background and Purpose-This study examines whether lesion shape documented on magnetic resonance diffusion-weighted imaging during acute stroke improves the prediction of the final infarct volume compared with lesion volume only. Methods-Diffusion-weighted imaging data and clinical information were retrospectively reviewed in 110 consecutive patients who underwent (n=67) or not (n=43) thrombolytic therapy for acute ischemic stroke. Three-dimensional shape analysis was performed on admission diffusion-weighted imaging data and 5 shape descriptors were developed. Final infarct volume was measured on T2-fluid-attenuated inversion recovery imaging data performed 30 days after stroke. Results-Shape analysis of acute ischemic lesion and more specifically the ratio of the bounding box volume to the lesion volume before thrombolytic treatment improved the prediction of the final infarct for patients undergoing thrombolysis (R2=0.86 in model with volume; R2=0.98 in model with volume and shape). Conclusions-Our findings suggest that lesion shape contains important predictive information and reflects important environmental factors that might determine the progression of ischemia from the core.

Original languageEnglish
Pages (from-to)976-981
Number of pages6
JournalStroke
Volume46
Issue number4
DOIs
Publication statusPublished - 2015 Apr 20
Externally publishedYes

Keywords

  • MRI
  • stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

Fingerprint

Dive into the research topics of 'Validity of Shape as a Predictive Biomarker of Final Infarct Volume in Acute Ischemic Stroke'. Together they form a unique fingerprint.

Cite this