Validation of the Japanese version of HFS-14, a disease-specific quality of life scale for patients suffering from hand-foot syndrome

Naoko Mikoshiba, Noriko Yamamoto-Mitani, Kazuki Sato, Yoshinari Asaoka, Takamasa Ohki, Misato Ohata, Mitsunori Miyashita

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to develop a Japanese version of hand-foot syndrome (HFS)-specific quality of life (QOL) questionnaire (HFS-14) to evaluate and monitor the QOL of patients with a possibility of HFS. Methods: The original English version of HFS-14 was translated and slightly modified into Japanese, and the Japanese HFS-14 was administered to 187 patients receiving chemotherapy with high risk of developing HFS as outpatients in four institutions in Japan. Factor validity, internal consistency, correlation with the Skindex-16 and Dermatology Life Quality Index (DLQI) scores, known group validity, and test-retest reliability were analyzed for 105 patients who developed HFS. Next, we compared HFS-14 with DLQI and Skindex-16. Results: Factor analysis confirmed the factor structure (one putative scale) of the Japanese HFS-14. Cronbach’s alpha was over 0.90. The Japanese HFS-14 score was correlated with the Skindex-16 and DLQI score. Intra-class correlation coefficients were over 0.80. Patients with severe HFS reported significantly poorer HFS-14 score than those with mild HFS. The Skindex-16 and DLQI scores were also significantly different in patients with different Common Terminology Criteria for Adverse Events (CTCAE) grades, but with smaller effect sizes than those for the HFS-14 score. Conclusions: The Japanese HFS-14 provides a valid and reliable score for monitoring and evaluating HFS.

Original languageEnglish
Pages (from-to)2739-2745
Number of pages7
JournalSupportive Care in Cancer
Volume23
Issue number9
DOIs
Publication statusPublished - 2015 Oct 1

Keywords

  • Hand-foot syndrome
  • Quality of life
  • Questionnaire
  • Validation

ASJC Scopus subject areas

  • Oncology

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