Validation of an ion trap tandem mass spectrometric analysis of mulberry 1-deoxynojirimycin in human plasma: Application to pharmacokinetic studies

Kiyotaka Nakagawa; Hiroyuki Kubota; Tsuyoshi Tsuzuki; Jun Kariya; Toshiyuki Kimura; Shinichi Oikawa; Teruo Miyazawa

doi:10.1271/bbb.80200

Validation of an ion trap tandem mass spectrometric analysis of mulberry 1-deoxynojirimycin in human plasma: Application to pharmacokinetic studies

Kiyotaka Nakagawa, Hiroyuki Kubota, Tsuyoshi Tsuzuki, Jun Kariya, Toshiyuki Kimura, Shinichi Oikawa, Teruo Miyazawa

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Mulberry 1-deoxynojirimycin (DNJ) is a potent α-glucosidase inhibitor. Although it is useful for the treatment of diabetes, the human absorption and metabolism of DNJ have never been characterized. We developed a method using hydrophilic interaction chromatography coupled with ion trap tandem mass spectrometry, and found that orally administered DNJ was absorbed into the blood and then excreted into the urine.

Original language	English
Pages (from-to)	2210-2213
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	72
Issue number	8
DOIs	https://doi.org/10.1271/bbb.80200
Publication status	Published - 2008

Keywords

1-deoxynojirimycin
Absorption
Human plasma
Mulberry
Tandem mass spectrometry

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1271/bbb.80200

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Validation of an ion trap tandem mass spectrometric analysis of mulberry 1-deoxynojirimycin in human plasma : Application to pharmacokinetic studies. / Nakagawa, Kiyotaka; Kubota, Hiroyuki; Tsuzuki, Tsuyoshi; Kariya, Jun; Kimura, Toshiyuki; Oikawa, Shinichi; Miyazawa, Teruo.

In: Bioscience, Biotechnology and Biochemistry, Vol. 72, No. 8, 2008, p. 2210-2213.

Research output: Contribution to journal › Article › peer-review

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abstract = "Mulberry 1-deoxynojirimycin (DNJ) is a potent α-glucosidase inhibitor. Although it is useful for the treatment of diabetes, the human absorption and metabolism of DNJ have never been characterized. We developed a method using hydrophilic interaction chromatography coupled with ion trap tandem mass spectrometry, and found that orally administered DNJ was absorbed into the blood and then excreted into the urine.",

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author = "Kiyotaka Nakagawa and Hiroyuki Kubota and Tsuyoshi Tsuzuki and Jun Kariya and Toshiyuki Kimura and Shinichi Oikawa and Teruo Miyazawa",

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AU - Nakagawa, Kiyotaka

AU - Kubota, Hiroyuki

AU - Tsuzuki, Tsuyoshi

AU - Kariya, Jun

AU - Kimura, Toshiyuki

AU - Oikawa, Shinichi

AU - Miyazawa, Teruo

N1 - Funding Information: This work was supported by the Supporting Program for Creating University Ventures, Japan Science and Technology Agency. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2008

Y1 - 2008

N2 - Mulberry 1-deoxynojirimycin (DNJ) is a potent α-glucosidase inhibitor. Although it is useful for the treatment of diabetes, the human absorption and metabolism of DNJ have never been characterized. We developed a method using hydrophilic interaction chromatography coupled with ion trap tandem mass spectrometry, and found that orally administered DNJ was absorbed into the blood and then excreted into the urine.

AB - Mulberry 1-deoxynojirimycin (DNJ) is a potent α-glucosidase inhibitor. Although it is useful for the treatment of diabetes, the human absorption and metabolism of DNJ have never been characterized. We developed a method using hydrophilic interaction chromatography coupled with ion trap tandem mass spectrometry, and found that orally administered DNJ was absorbed into the blood and then excreted into the urine.

KW - 1-deoxynojirimycin

KW - Absorption

KW - Human plasma

KW - Mulberry

KW - Tandem mass spectrometry

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Validation of an ion trap tandem mass spectrometric analysis of mulberry 1-deoxynojirimycin in human plasma: Application to pharmacokinetic studies

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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