Abstract
Mulberry 1-deoxynojirimycin (DNJ) is a potent α-glucosidase inhibitor. Although it is useful for the treatment of diabetes, the human absorption and metabolism of DNJ have never been characterized. We developed a method using hydrophilic interaction chromatography coupled with ion trap tandem mass spectrometry, and found that orally administered DNJ was absorbed into the blood and then excreted into the urine.
Original language | English |
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Pages (from-to) | 2210-2213 |
Number of pages | 4 |
Journal | Bioscience, Biotechnology and Biochemistry |
Volume | 72 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2008 |
Keywords
- 1-deoxynojirimycin
- Absorption
- Human plasma
- Mulberry
- Tandem mass spectrometry
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry