Validation of an ion trap tandem mass spectrometric analysis of mulberry 1-deoxynojirimycin in human plasma: Application to pharmacokinetic studies

Kiyotaka Nakagawa; Hiroyuki Kubota; Tsuyoshi Tsuzuki; Jun Kariya; Toshiyuki Kimura; Shinichi Oikawa; Teruo Miyazawa

doi:10.1271/bbb.80200

Validation of an ion trap tandem mass spectrometric analysis of mulberry 1-deoxynojirimycin in human plasma: Application to pharmacokinetic studies

Kiyotaka Nakagawa, Hiroyuki Kubota, Tsuyoshi Tsuzuki, Jun Kariya, Toshiyuki Kimura, Shinichi Oikawa, Teruo Miyazawa

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Mulberry 1-deoxynojirimycin (DNJ) is a potent α-glucosidase inhibitor. Although it is useful for the treatment of diabetes, the human absorption and metabolism of DNJ have never been characterized. We developed a method using hydrophilic interaction chromatography coupled with ion trap tandem mass spectrometry, and found that orally administered DNJ was absorbed into the blood and then excreted into the urine.

Original language	English
Pages (from-to)	2210-2213
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	72
Issue number	8
DOIs	https://doi.org/10.1271/bbb.80200
Publication status	Published - 2008

Keywords

1-deoxynojirimycin
Absorption
Human plasma
Mulberry
Tandem mass spectrometry

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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Validation of an ion trap tandem mass spectrometric analysis of mulberry 1-deoxynojirimycin in human plasma : Application to pharmacokinetic studies. / Nakagawa, Kiyotaka; Kubota, Hiroyuki; Tsuzuki, Tsuyoshi; Kariya, Jun; Kimura, Toshiyuki; Oikawa, Shinichi; Miyazawa, Teruo.

In: Bioscience, Biotechnology and Biochemistry, Vol. 72, No. 8, 2008, p. 2210-2213.

Research output: Contribution to journal › Article › peer-review

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author = "Kiyotaka Nakagawa and Hiroyuki Kubota and Tsuyoshi Tsuzuki and Jun Kariya and Toshiyuki Kimura and Shinichi Oikawa and Teruo Miyazawa",

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AU - Tsuzuki, Tsuyoshi

AU - Kariya, Jun

AU - Kimura, Toshiyuki

AU - Oikawa, Shinichi

AU - Miyazawa, Teruo

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KW - Mulberry

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