Validation of an ion trap tandem mass spectrometric analysis of mulberry 1-deoxynojirimycin in human plasma: Application to pharmacokinetic studies

Kiyotaka Nakagawa, Hiroyuki Kubota, Tsuyoshi Tsuzuki, Jun Kariya, Toshiyuki Kimura, Shinichi Oikawa, Teruo Miyazawa

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

Mulberry 1-deoxynojirimycin (DNJ) is a potent α-glucosidase inhibitor. Although it is useful for the treatment of diabetes, the human absorption and metabolism of DNJ have never been characterized. We developed a method using hydrophilic interaction chromatography coupled with ion trap tandem mass spectrometry, and found that orally administered DNJ was absorbed into the blood and then excreted into the urine.

Original languageEnglish
Pages (from-to)2210-2213
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume72
Issue number8
DOIs
Publication statusPublished - 2008

Keywords

  • 1-deoxynojirimycin
  • Absorption
  • Human plasma
  • Mulberry
  • Tandem mass spectrometry

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Validation of an ion trap tandem mass spectrometric analysis of mulberry 1-deoxynojirimycin in human plasma: Application to pharmacokinetic studies'. Together they form a unique fingerprint.

Cite this