Utilizing nonlinear behavior of microbubbles in medical ultrasound

Shin Ichiro Umemura, Ken Ichi Kawabata, Kazuaki Sasaki

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Microbubbles exposed to ultrasound exhibit extremely nonlinear conspicuous behaviors. Medical imaging makes wide use of the pulse inversion method, in which only this nonlinear component is extracted by adding the received signals obtained by sending the phase inverted ultrasonic pulses twice. Further, there have been research efforts to use this nonlinear behavior for sonochemical healing of tumors by the efficient generation of acoustic cavitation by illumination with the second harmonic superimposed on the fundamental wave.

Original languageEnglish
Pages (from-to)63-69
Number of pages7
JournalElectronics and Communications in Japan, Part III: Fundamental Electronic Science (English translation of Denshi Tsushin Gakkai Ronbunshi)
Issue number8
Publication statusPublished - 2007 Aug 1


  • Microbubbles
  • Nonlinear behavior
  • Pulse inversion method
  • Second harmonic superposition
  • Sonodynamic healing

ASJC Scopus subject areas

  • Electrical and Electronic Engineering


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