Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice

Masaaki Waragai, Saori Hata, Toshiharu Suzuki, Ryotaro Ishii, Chihiro Fujii, Takahiko Tokuda, Hiroyuki Arai, Takashi Ohrui, Susumu Higuchi, Madoka Yoshida, Kazuei Igarashi, Masaru Moriya, Naomichi Iwai, Kenichi Uemura

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

We validated the utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy (1H MRS) as an adjunct screening technique for dementia due to Alzheimer's disease (AD). We examined the posterior cingulate gyri of 228 subjects using VSRAD and 1H MRS in addition to conventional cerebrospinal fluid biomarkers at baseline. At the 3-year follow-up, the 228 subject were classified as follows: 93 healthy subjects, 42 MCI-non-converters (MCI-NC), 25 MCI-converters to AD (MCI-C), 44 AD, 8 dementia with Lewy bodies (DLB), 5 normal pressure hydrocephalus, and 11 patients with other neurological diseases. Our results demonstrated that subjects with increased medial temporal atrophy (MTA) severity on VSRAD, increased Cho/Cr, MI/Cr ratio, and decreased NAA/Cr and NAA/MI ratio on 1H MRS at baseline were at risk of dementia due to AD. Receiver operating characteristic analysis showed that severity of MTA and the NAA/MI ratio distinguished patients with AD and MCI-C from controls. Furthermore, the 118 subjects without dementia and MTA showing only a decreased NAA/MI ratio at baseline developed to MCI-C, AD, and DLB 3 years later. 1H MRS detected biochemical abnormalities preceding brain atrophy and cognitive decline. VSRAD combined with 1H MRS may be routinely applied to screen for MCI/AD and prodromal AD in clinical practice.

Original languageEnglish
Pages (from-to)1207-1222
Number of pages16
JournalJournal of Alzheimer's Disease
Volume41
Issue number4
DOIs
Publication statusPublished - 2014

Keywords

  • Alzheimer's disease
  • SPM8 plus DARTEL (VSRAD)
  • magnetic resonance imaging
  • magnetic resonance spectroscopy (H MRS)
  • screening
  • surrogate marker

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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