Utility of measuring circulating tumor cell counts to assess the efficacy of treatment for carcinomas of unknown primary origin

Keigo Komine, Masahiro Inoue, Kazunori Otsuka, Koji Fukuda, Hiroshi Nanjo, Hiroyuki Shibata

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Background/Aim: Carcinomas of unknown primary origin (CUPs) account for 3%-5% of all malignancies. The majority of CUPs have unfavorable prognosis and are chemoresistant. Predictive biomarkers should be established to improve therapeutic outcomes. Metastatic ability of CUPs may be related to the existence of circulating tumor cells (CTCs). Patients and Methods: Ten patients diagnosed with CUP visiting the Akita University Hospital participated in this study. CTCs were calculated by the CellSearch system. Results: The present observational study indicates that CTCs were detected in 50% of CUPs, and in 80% chemotherapeutically-naïve cases. Furthermore, decrease in CTC count between the pre-treatment and posttreatment phases were observed in chemosensitive cases. Conclusion: Rapid assessment of the efficacy of chemotherapy by CTC count may become a useful predictive biomarker of CUPs.

Original languageEnglish
Pages (from-to)3165-3168
Number of pages4
JournalAnticancer research
Volume34
Issue number6
Publication statusPublished - 2014 Jun 1
Externally publishedYes

Keywords

  • Biomarker
  • Carcinomas of unknown primary origin
  • Chemotherapy
  • Circulating tumor cell
  • Prediction

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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