Utility of cyclodextrin in mobile phase for high-performance liquid chromatographic separation of bufadienolides

Kazutake Shimada, Youko Kurata, Tomoyuki Oe

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

The chromatographic behavior of bufadienolides including conjugates was examined by the addition of Y-cyclodextrin to the mobile phase in reversed-phase high-performance liquid chromatography. The capacity factor of sulfate or glucuronide was decreased sharply by the additive. The separation of bufadienolides, unseparable under the usual method, was much improved by the addition of y-cyclodextrin.

Original languageEnglish
Pages (from-to)493-504
Number of pages12
JournalJournal of Liquid Chromatography
Volume13
Issue number3
DOIs
Publication statusPublished - 1990 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine

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