Utility of co-transplanting mesenchymal stem cells in islet transplantation

Naoaki Sakata, Masafumi Goto, Gumpei Yoshimatsu, Shinichi Egawa, Michiaki Unno

Research output: Contribution to journalReview articlepeer-review

26 Citations (Scopus)

Abstract

Islet transplantation is characterized by the transplantation of isolated islets from donor pancreata into a diabetic recipient. Although it is a viable choice in the treatment of insulin dependent diabetes mellitus, most patients (approximately 90%) require insulin five years after transplantation. Recently, the co-transplantation of mesenchymal stem cells (MSCs) and islets in animal studies has revealed the effectiveness of MSCs co-transplantation for improving islet function. The mechanisms underlying the beneficial impact of MSCs include immunomodulation and the promotion of angiogenesis. In this review, we discuss MSCs and how they support improved graft survival and function.

Original languageEnglish
Pages (from-to)5150-5155
Number of pages6
JournalWorld Journal of Gastroenterology
Volume17
Issue number47
DOIs
Publication statusPublished - 2011

Keywords

  • Angiogenesis
  • Bone marrow
  • Diabetes mellitus
  • Immunomodulatory
  • Islet transplantation
  • Mesenchymal stem cell
  • Regulatory T cell
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Gastroenterology

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