Utility of B-Mode, Color Doppler and Elastography in the Diagnosis of Breast Cancer: Results of the CD-CONFIRM Multicenter Study of 1351 Breast Solid Masses

Takanori Watanabe, Takuhiro Yamaguchi, Toshitaka Okuno, Sachiyo Konno, Rie Takaki, Megumi Sato, Masahiko Tsuruoka, Hideaki Shirai, Yukari Ogawa, Kanako Ban, Yasuhisa Fujimoto, Koichi Hirokaga, Ryoji Watanabe, Takako Morita

Research output: Contribution to journalArticlepeer-review

Abstract

The usefulness of color Doppler ultrasound (CD) in distinguishing between benign and malignant breast lesions remains controversial. Our prior study, the Japan Association of Breast and Thyroid Sonology (JABTS) BC-04 study (malignant: 839, benign: 569), found CD was useful in breast cancer diagnosis, and we developed CD diagnostic criteria. The first aim of the current study (the CD-CONFIRM study) was to evaluate the usefulness of the CD diagnostic criteria. The second aim was to evaluate the relationship between CD and elastography. We evaluated ultrasound images of breast masses from 13 institutions (malignant: 639, benign: 712). While the sensitivity of B-mode alone was very high and was not significantly improved with CD, the specificity was significantly improved with CD (61.2%–69.2%, p < 0.0001). Furthermore, the specificity of the combination of B-mode and CD improved significantly with the addition of elastography (72.8%–79.0%, p < 0.0001). This study found that the CD criteria are useful, and CD and elastography are independent.

Original languageEnglish
Pages (from-to)3111-3121
Number of pages11
JournalUltrasound in Medicine and Biology
Volume47
Issue number11
DOIs
Publication statusPublished - 2021 Nov

Keywords

  • Breast cancer
  • Color Doppler
  • Diagnostic criteria
  • Elastography
  • Multicenter study
  • Ultrasound

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics

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