Uterine angiomyolipoma: Case report and review of the literature

Hiroshi Yaegashi, Takuya Moriya, Syu Soeda, Yukinori Yonemoto, Hiroshi Nagura, Hironobu Sasano

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


Extrarenal angiomyolipomas (AML) have been reported at various anatomical sites, but infrequently in the gynecological region. In the uterus, only a few cases have been described. We describe a uterine angiomyolipoma occurring in a 40-year-old woman without evidence of tuberous sclerosis. The tumor arose on the right wall of the uterine body and was partially cystic, and it was associated with marked degeneration. It was composed of mature adipose tissue, anomalous blood vessels and non-vascular smooth muscle cells. Immunohistochemistry revealed that non-vascular smooth muscle cells were positive for a-smooth muscle actin (α-SMA), desmin, vimentin, antihuman muscle actin (HHF35) and progesterone receptor (PR), and negative for cytokeratin, antihuman melanoma (HMB45), CD34, S-100 and estrogen receptor (ER). It is of particular interest that non-vascular smooth muscle cells were negative for HMB45, in contrast to renal and other extrarenal AML in which HMB45 immunoreactivity has been demonstrated in these cells.

Original languageEnglish
Pages (from-to)896-901
Number of pages6
JournalPathology international
Issue number11
Publication statusPublished - 2001


  • Estrogen receptor (ER)
  • HMB45
  • Progesterone receptor (PR)
  • Smooth muscle cells
  • Uterine angiomyolipoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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