TY - JOUR
T1 - Uterine angiomyolipoma
T2 - Case report and review of the literature
AU - Yaegashi, Hiroshi
AU - Moriya, Takuya
AU - Soeda, Syu
AU - Yonemoto, Yukinori
AU - Nagura, Hiroshi
AU - Sasano, Hironobu
PY - 2001
Y1 - 2001
N2 - Extrarenal angiomyolipomas (AML) have been reported at various anatomical sites, but infrequently in the gynecological region. In the uterus, only a few cases have been described. We describe a uterine angiomyolipoma occurring in a 40-year-old woman without evidence of tuberous sclerosis. The tumor arose on the right wall of the uterine body and was partially cystic, and it was associated with marked degeneration. It was composed of mature adipose tissue, anomalous blood vessels and non-vascular smooth muscle cells. Immunohistochemistry revealed that non-vascular smooth muscle cells were positive for a-smooth muscle actin (α-SMA), desmin, vimentin, antihuman muscle actin (HHF35) and progesterone receptor (PR), and negative for cytokeratin, antihuman melanoma (HMB45), CD34, S-100 and estrogen receptor (ER). It is of particular interest that non-vascular smooth muscle cells were negative for HMB45, in contrast to renal and other extrarenal AML in which HMB45 immunoreactivity has been demonstrated in these cells.
AB - Extrarenal angiomyolipomas (AML) have been reported at various anatomical sites, but infrequently in the gynecological region. In the uterus, only a few cases have been described. We describe a uterine angiomyolipoma occurring in a 40-year-old woman without evidence of tuberous sclerosis. The tumor arose on the right wall of the uterine body and was partially cystic, and it was associated with marked degeneration. It was composed of mature adipose tissue, anomalous blood vessels and non-vascular smooth muscle cells. Immunohistochemistry revealed that non-vascular smooth muscle cells were positive for a-smooth muscle actin (α-SMA), desmin, vimentin, antihuman muscle actin (HHF35) and progesterone receptor (PR), and negative for cytokeratin, antihuman melanoma (HMB45), CD34, S-100 and estrogen receptor (ER). It is of particular interest that non-vascular smooth muscle cells were negative for HMB45, in contrast to renal and other extrarenal AML in which HMB45 immunoreactivity has been demonstrated in these cells.
KW - Estrogen receptor (ER)
KW - HMB45
KW - Progesterone receptor (PR)
KW - Smooth muscle cells
KW - Uterine angiomyolipoma
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U2 - 10.1046/j.1440-1827.2001.01289.x
DO - 10.1046/j.1440-1827.2001.01289.x
M3 - Article
C2 - 11844059
AN - SCOPUS:0035725985
VL - 51
SP - 896
EP - 901
JO - Acta Pathologica Japonica
JF - Acta Pathologica Japonica
SN - 1320-5463
IS - 11
ER -