Usefulness of preoperative low dose cisplatin treatment for advanced esophageal cancer

Masayuki Imamura, Yutaka Shimada, Yuhji Kanda, Manabu Fukumoto, Ken Yanagibashi, Tokiharu Miyahara, Takayoshi Tobe

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

In order to decrease the perioperative complications by preoperative cisplatin chemotherapy, the preoperative single administration of cisplatin (30 mg/m2) was performed weekly from one to six times in 36 consecutive patients with esophageal cancer classified as higher than Stage II. The survival curve of 17 patients in Stage III was significantly better (P<0.05) than that of patients who had been treated without preoperative cisplatin treatment. In 3 of the 12 patients who had locally invasive cancer, either the main tumors or the metastatic lymph nodes, which had invaded the trachea or the left main bronchus, sufficiently receded, so that a curative esophagectomy became possible; 2 of them have survived over 33 months while 1 died of pneumonia 33 months after surgery. The number of perioperative complications was minimal, and thus, we consider that the postoperative use of cisplatin and fluorouracil is indicated in patients in whom a histological response is noted in the resected specimens.

Original languageEnglish
Pages (from-to)409-415
Number of pages7
JournalSurgery today
Volume22
Issue number5
DOIs
Publication statusPublished - 1992 Sep 1

Keywords

  • esophageal cancer
  • preoperative cisplatin treatment

ASJC Scopus subject areas

  • Surgery

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