Usefulness of painDETECT and S-LANSS in identifying the neuropathic component of mixed pain among patients with tumor-related cancer pain

Takahiro Higashibata, Keita Tagami, Tomofumi Miura, Ayumi Okizaki, Yuki Sumazaki Watanabe, Yoshihisa Matsumoto, Tatsuya Morita, Hiroya Kinoshita

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Tumor-related cancer pain often comprises mixed pain with both nociceptive and neuropathic components. Whether tumor-related cancer pain includes a neuropathic component impacts the therapeutic strategy. The aim of this cross-sectional study was to investigate the usefulness of two screening tools for neuropathic pain, painDETECT and Self-Report Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS), in identifying the neuropathic component of mixed pain among patients with tumor-related cancer pain. Method: This cross-sectional study recruited consecutive inpatients and outpatients at a single site. The diagnostic accuracy of painDETECT and S-LANSS was evaluated using receiver operating characteristic curve analysis and classification probability. Results: Of the study group, 106 patients had tumor-related cancer pain. Analyses of the nociceptive and mixed pain groups (n = 104) showed that neither painDETECT nor S-LANSS had satisfactory areas under the curve (AUCs) for identifying the neuropathic component of mixed pain (0.59 for painDETECT and 0.56 for S-LANSS). By pain intensity, the AUC for painDETECT was significantly higher in the mild pain group than in the moderate or severe pain group (0.77 vs. 0.43, P = 0.002). All parameters of classification probability for both tools were higher in the mild pain group than in the moderate or severe pain group. Conclusions: painDETECT and S-LANSS could not identify the neuropathic component of mixed pain among patients with tumor-related cancer pain, especially when pain was moderate or severe. Contrarily, these screening tools might be useful for identifying the neuropathic component of mixed pain for mild pain.

Original languageEnglish
Pages (from-to)279-285
Number of pages7
JournalSupportive Care in Cancer
Volume28
Issue number1
DOIs
Publication statusPublished - 2020 Jan 1

Keywords

  • Cancer pain
  • Cross-sectional study
  • Mixed pain
  • Neuropathic pain
  • S-LANSS
  • painDETECT

ASJC Scopus subject areas

  • Oncology

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