Usefulness of LigaSure for liver resection: analysis by randomized clinical trial

Akio Saiura, Junji Yamamoto, Rintaro Koga, Yoshihiro Sakamoto, Norihiro Kokudo, Makoto Seki, Takuhiro Yamaguchi, Toshiharu Yamaguchi, Tetsuichiro Muto, Masatoshi Makuuchi

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116 Citations (Scopus)

Abstract

Background: The goal of the present study was to evaluate the efficacy of the novel LigaSure Vessel Sealing System (Valleylab, Boulder, CO) when used for liver resection. Methods: Sixty patients (n = 30 in each group) with liver pathology from a single center were randomized to undergo liver resection with either the LigaSure system or with conventional clamping methods. Patients were stratified according to tumor size (<5 or >5 cm), type of hepatectomy (minor or major), and liver damage (normal or injured). Estimated blood loss during liver transection was used as the primary end point, whereas liver transection speed and morbidity rate were used as secondary end points. Results: There were no hospital deaths. The median blood loss during liver transection was less in the LigaSure than in the conventional group (200 vs 322 mL; P = .185). The amount of blood loss during minor hepatectomy was significantly less in the LigaSure than in the conventional group (186 vs 412 mL, P = .012). The liver transection speed was significantly faster in the LigaSure than in the conventional group (2.3 vs 1.6 cm2/min, P < .001. The number of ties required during liver transection was significantly less in the LigaSure than in the conventional group (6 vs 69 ties, P < .001). The morbidity rate was similar when comparing the 2 groups, indicating that the LigaSure sealing device and conventional methods had comparable efficacy in sealing the bile duct in the portal triad. Postoperative bile leak was observed in 1 patient (3%) in the LigaSure group and in 3 patients (9%) in the conventional group (P = .301). Conclusions: The LigaSure system is an effective and safe tool for decreasing liver resection time.

Original languageEnglish
Pages (from-to)41-45
Number of pages5
JournalAmerican Journal of Surgery
Volume192
Issue number1
DOIs
Publication statusPublished - 2006 Jul
Externally publishedYes

Keywords

  • Blood loss
  • LigaSure
  • Liver resection
  • Randomized clinical trial

ASJC Scopus subject areas

  • Surgery

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  • Cite this

    Saiura, A., Yamamoto, J., Koga, R., Sakamoto, Y., Kokudo, N., Seki, M., Yamaguchi, T., Yamaguchi, T., Muto, T., & Makuuchi, M. (2006). Usefulness of LigaSure for liver resection: analysis by randomized clinical trial. American Journal of Surgery, 192(1), 41-45. https://doi.org/10.1016/j.amjsurg.2006.01.025