Usefulness of Inflammation-Based Prognostic Score in Patients Undergoing Lung Metastasectomy for Colorectal Carcinoma

Satoru Kobayashi, Yoko Karube, Morimichi Nishihira, Takashi Inoue, Osamu Araki, Tetsu Sado, Masayuki Chida

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: There is increasing evidence that Glasgow Prognostic Score (GPS), based on systemic inflammatory response and albumin level, is a useful predictor of overall survival in patients with various types of cancer. Methods: Patients with lung metastasis from colorectal carcinoma who underwent a lung metastasectomy from 2000 to 2015 were retrospectively investigated. Routine laboratory measurements including serum C-reactive protein (CRP), albumin, and the tumor marker carcinoembryonic antigen were performed before the metastasectomy. Results: Ninety-nine patients underwent 132 lung metastasectomy procedures during the study period. Kaplan–Meier analysis revealed that GPS (p = 0.017), number of metastases (p = 0.004), and the presence of liver metastasis (p = 0.010) were associated with overall survival, while univariate analysis selected GPS (p = 0.028), number of metastases (p = 0.005), and liver metastasis (p = 0.014) as predictive factors associated with overall survival. Multivariate analysis also indicated GPS (p = 0.004), number of metastases (p = 0.004), and liver metastasis (p = 0.013) as predictive factors associated with overall survival. Conclusion: In addition to number of metastases and liver metastasis, GPS is an important predictor of overall survival in colorectal cancer patients who undergo a lung metastasectomy.

Original languageEnglish
Pages (from-to)1632-1637
Number of pages6
JournalWorld Journal of Surgery
Volume40
Issue number7
DOIs
Publication statusPublished - 2016 Jul 1
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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