Usefulness of asialoglycoprotein receptor imaging for the evaluation of liver metastasis of neuroblastoma

Tomohiro Kaneta, Takashi Hakamatsuka, Hiroshi Ito, Shin Maruoka, Hiroshi Fukuda, Shoki Takahashi, Shogo Yamada

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Neuroblastoma, derived from the neural crest ectoderm, is the most common type of solid abdominal mass seen in infancy. The diagnosis, staging, and follow-up of neuroblastoma are often performed using metaiodobenzylguanidine (MIBG) imaging. However, the evaluation of liver metastasis by this method is complicated by the normal physiological uptake of MIBG by the liver. The asialoglycoprotein receptor is a hepatic cell-surface receptor specific for galactose-terminated glycoprotein, and 99mTc-DTPA-galactosyl human serum albumin (GSA) accumulates selectively in hepatic cells. Here, we report a case of congenital neuroblastoma with liver metastasis in which GSA scans were useful for differentiation between normal and metastatic sites in the liver.

Original languageEnglish
Pages (from-to)355-358
Number of pages4
JournalAnnals of Nuclear Medicine
Volume18
Issue number4
DOIs
Publication statusPublished - 2004 Jun

Keywords

  • Asialoglycoprotein
  • GSA
  • Liver metastasis
  • MIBG
  • Neuroblastoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Kaneta, T., Hakamatsuka, T., Ito, H., Maruoka, S., Fukuda, H., Takahashi, S., & Yamada, S. (2004). Usefulness of asialoglycoprotein receptor imaging for the evaluation of liver metastasis of neuroblastoma. Annals of Nuclear Medicine, 18(4), 355-358. https://doi.org/10.1007/BF02984476