Use of the kinase inhibitor analog 1NM-PP1 reveals a role for toxoplasma gondii CDPK1 in the invasion step

Tatsuki Sugi, Kentaro Kato, Kyosuke Kobayashi, Shumpei Watanabe, Hitomi Kurokawa, Haiyan Gong, Kishor Pandey, Hitoshi Takemae, Hiroomi Akashi

Research output: Contribution to journalComment/debatepeer-review

44 Citations (Scopus)

Abstract

Toxoplasma gondii CDPK1 (TgCDPK1) was found to be the target of the toxoplasmocidal compound 1NM-PP1. When TgCDPK1 was mutated at position 128 from glycine to methionine, resistance was gained. Inhibition of gliding motility without inhibition of micronemal secretion by 1NM-PP1 suggests a function for TgCDPK1 in gliding motility.

Original languageEnglish
Pages (from-to)667-670
Number of pages4
JournalEukaryotic Cell
Volume9
Issue number4
DOIs
Publication statusPublished - 2010 Apr

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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