Use of sugammadex in patients for caesarean section undergoing general anesthesia with rocuronium

Masakazu Shibusawa, Yutaka Ejima, Ryou Nishino, Hiroaki Toyama, Shin Kurosawa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Recently, rocuronium is being used in patients for caesarean section undergoing general anesthesia instead of suxamethonium. An increased dose of rocuronium improves intubating conditions but prolongs neuromuscular blockade. Sugammadex reverses rapidly and predictably even profound rocuronium-induced neuromuscular blockade. We experienced 13 cases of caesarean section patients undergoing general anesthesia with thiopental (3.5 mg·kg -1) and rocuronium (0.9 mg·kg -1). At the end of surgery, sugammadex (2 mg·kg -1) was administered every 3 minutes repeatedly until TOF>0.9. In two patients, neuromuscular blockade spontaneously recovered to TOF>0.9 at the end of surgery. In most patients administered sugammadex, TOF recovered to more than 0.9 within a few minutes. However, in one patient who had chronic renal failure (creatinine clearance rate : 12 ml·min -1), 10 minutes were required for TOF to recover to more than 0.7, and TOF never reached 0.9. All patients were successfully intubated at the first attempt. No signs of recurarization or adverse effects related to sugammadex were noted in the perioperative period.

Original languageEnglish
Pages (from-to)805-809
Number of pages5
JournalJapanese Journal of Anesthesiology
Volume61
Issue number8
Publication statusPublished - 2012 Aug 1

Keywords

  • Caesarean section
  • Rocuronium
  • Sugammadex

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Fingerprint Dive into the research topics of 'Use of sugammadex in patients for caesarean section undergoing general anesthesia with rocuronium'. Together they form a unique fingerprint.

  • Cite this