Use of reference tissue models for quantification of histamine H 1 receptors in human brain by using positron emission tomography and [11C]doxepin

Atsuro Suzuki, Manabu Tashiro, Yuichi Kimura, Hideki Mochizuki, Kenji Ishii, Hiroshi Watabe, Kazuhiko Yanai, Kiichi Ishiwata, Keizo Ishii

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The aim of the present study is to evaluate the validity of the simplified reference tissue model (SRTM) and of Logan graphical analysis with reference tissue (LGAR) for quantification of histamine H1 receptors (H1Rs) by using positron emission tomography (PET) with [11C]doxepin. These model-based analytic methods (SRTM and LGAR) are compared to Logan graphical analysis (LGA) and to the one-tissue model (1TM), using complete datasets obtained from 5 healthy volunteers. Since H1R concentration in the cerebellum can be regarded as negligibly small, the cerebellum was selected as the reference tissue in the present study. The comparison of binding potential (BP) values estimated by LGAR and 1TM showed good agreement; on the other hand, SRTM turned out to be unstable concerning parameter estimation in several regions of the brain. By including the results of noise analysis, LGAR became a reliable method for parameter estimation of [11C]doxepin data in the cortical regions.

Original languageEnglish
Pages (from-to)425-433
Number of pages9
JournalAnnals of Nuclear Medicine
Volume19
Issue number6
DOIs
Publication statusPublished - 2005 Sep

Keywords

  • Model-based analysis
  • PET

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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