TY - JOUR
T1 - Use of plant hormones to activate silent polyketide biosynthetic pathways in
T2 - Arthrinium sacchari, a fungus isolated from a spider
AU - Morishita, Yohei
AU - Okazaki, Yusuke
AU - Luo, Yi Yi
AU - Nunoki, Jun
AU - Taniguchi, Tohru
AU - Oshima, Yoshiteru
AU - Asai, Teigo
N1 - Funding Information:
We thank Prof. K. Gomi (Tohoku University) for kindly providing the expression vectors and the fungal strain and Prof. Y. Ohnishi and Dr T. Awakawa (The University of Tokyo) for kindly providing an A. oryzae transformant with ACAS and ACTE. This work was supported by JSPS KAKENHI (grant no. 26460117 and 17H05428) to T. Asai from Japan Society for the Promotion of Science (JSPS).
PY - 2019
Y1 - 2019
N2 - Plant hormones were evaluated for their ability to activate fungal secondary metabolite production. Three synthetic cytokinins, kinetin, 6-benzylaminopurine, and forchlorfenuron, showed remarkable enhancement of the production of aromatic polyketides derived from emodin in a fungus, Arthrinium sacchari, and allowed us to isolate a new polyketide. Furthermore, we firstly demonstrated the potential of plant hormones to activate a wide range of fungal secondary metabolite production processes.
AB - Plant hormones were evaluated for their ability to activate fungal secondary metabolite production. Three synthetic cytokinins, kinetin, 6-benzylaminopurine, and forchlorfenuron, showed remarkable enhancement of the production of aromatic polyketides derived from emodin in a fungus, Arthrinium sacchari, and allowed us to isolate a new polyketide. Furthermore, we firstly demonstrated the potential of plant hormones to activate a wide range of fungal secondary metabolite production processes.
UR - http://www.scopus.com/inward/record.url?scp=85060388018&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85060388018&partnerID=8YFLogxK
U2 - 10.1039/c8ob02837k
DO - 10.1039/c8ob02837k
M3 - Article
C2 - 30608107
AN - SCOPUS:85060388018
VL - 17
SP - 780
EP - 784
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
SN - 1477-0520
IS - 4
ER -