Use of plant hormones to activate silent polyketide biosynthetic pathways in: Arthrinium sacchari, a fungus isolated from a spider

Yohei Morishita; Yusuke Okazaki; Yi Yi Luo; Jun Nunoki; Tohru Taniguchi; Yoshiteru Oshima; Teigo Asai

doi:10.1039/c8ob02837k

Use of plant hormones to activate silent polyketide biosynthetic pathways in: Arthrinium sacchari, a fungus isolated from a spider

Yohei Morishita, Yusuke Okazaki, Yi Yi Luo, Jun Nunoki, Tohru Taniguchi, Yoshiteru Oshima, Teigo Asai

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Plant hormones were evaluated for their ability to activate fungal secondary metabolite production. Three synthetic cytokinins, kinetin, 6-benzylaminopurine, and forchlorfenuron, showed remarkable enhancement of the production of aromatic polyketides derived from emodin in a fungus, Arthrinium sacchari, and allowed us to isolate a new polyketide. Furthermore, we firstly demonstrated the potential of plant hormones to activate a wide range of fungal secondary metabolite production processes.

Original language	English
Pages (from-to)	780-784
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	17
Issue number	4
DOIs	https://doi.org/10.1039/c8ob02837k
Publication status	Published - 2019

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1039/c8ob02837k

Fingerprint Dive into the research topics of 'Use of plant hormones to activate silent polyketide biosynthetic pathways in: Arthrinium sacchari, a fungus isolated from a spider'. Together they form a unique fingerprint.

Cite this

Use of plant hormones to activate silent polyketide biosynthetic pathways in : Arthrinium sacchari, a fungus isolated from a spider. / Morishita, Yohei; Okazaki, Yusuke; Luo, Yi Yi; Nunoki, Jun; Taniguchi, Tohru; Oshima, Yoshiteru; Asai, Teigo.

In: Organic and Biomolecular Chemistry, Vol. 17, No. 4, 2019, p. 780-784.

Research output: Contribution to journal › Article › peer-review

@article{b4554c6efb6745ed96f92bf5df466702,

title = "Use of plant hormones to activate silent polyketide biosynthetic pathways in: Arthrinium sacchari, a fungus isolated from a spider",

abstract = "Plant hormones were evaluated for their ability to activate fungal secondary metabolite production. Three synthetic cytokinins, kinetin, 6-benzylaminopurine, and forchlorfenuron, showed remarkable enhancement of the production of aromatic polyketides derived from emodin in a fungus, Arthrinium sacchari, and allowed us to isolate a new polyketide. Furthermore, we firstly demonstrated the potential of plant hormones to activate a wide range of fungal secondary metabolite production processes.",

author = "Yohei Morishita and Yusuke Okazaki and Luo, {Yi Yi} and Jun Nunoki and Tohru Taniguchi and Yoshiteru Oshima and Teigo Asai",

note = "Funding Information: We thank Prof. K. Gomi (Tohoku University) for kindly providing the expression vectors and the fungal strain and Prof. Y. Ohnishi and Dr T. Awakawa (The University of Tokyo) for kindly providing an A. oryzae transformant with ACAS and ACTE. This work was supported by JSPS KAKENHI (grant no. 26460117 and 17H05428) to T. Asai from Japan Society for the Promotion of Science (JSPS).",

year = "2019",

doi = "10.1039/c8ob02837k",

language = "English",

volume = "17",

pages = "780--784",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "4",

}

TY - JOUR

T1 - Use of plant hormones to activate silent polyketide biosynthetic pathways in

T2 - Arthrinium sacchari, a fungus isolated from a spider

AU - Morishita, Yohei

AU - Okazaki, Yusuke

AU - Luo, Yi Yi

AU - Nunoki, Jun

AU - Taniguchi, Tohru

AU - Oshima, Yoshiteru

AU - Asai, Teigo

N1 - Funding Information: We thank Prof. K. Gomi (Tohoku University) for kindly providing the expression vectors and the fungal strain and Prof. Y. Ohnishi and Dr T. Awakawa (The University of Tokyo) for kindly providing an A. oryzae transformant with ACAS and ACTE. This work was supported by JSPS KAKENHI (grant no. 26460117 and 17H05428) to T. Asai from Japan Society for the Promotion of Science (JSPS).

PY - 2019

Y1 - 2019

N2 - Plant hormones were evaluated for their ability to activate fungal secondary metabolite production. Three synthetic cytokinins, kinetin, 6-benzylaminopurine, and forchlorfenuron, showed remarkable enhancement of the production of aromatic polyketides derived from emodin in a fungus, Arthrinium sacchari, and allowed us to isolate a new polyketide. Furthermore, we firstly demonstrated the potential of plant hormones to activate a wide range of fungal secondary metabolite production processes.

AB - Plant hormones were evaluated for their ability to activate fungal secondary metabolite production. Three synthetic cytokinins, kinetin, 6-benzylaminopurine, and forchlorfenuron, showed remarkable enhancement of the production of aromatic polyketides derived from emodin in a fungus, Arthrinium sacchari, and allowed us to isolate a new polyketide. Furthermore, we firstly demonstrated the potential of plant hormones to activate a wide range of fungal secondary metabolite production processes.

UR - http://www.scopus.com/inward/record.url?scp=85060388018&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060388018&partnerID=8YFLogxK

U2 - 10.1039/c8ob02837k

DO - 10.1039/c8ob02837k

M3 - Article

C2 - 30608107

AN - SCOPUS:85060388018

VL - 17

SP - 780

EP - 784

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

SN - 1477-0520

IS - 4

ER -