Use of olanzapine for the relief of nausea and vomiting in patients with advanced cancer: a multicenter survey in Japan

Keisuke Kaneishi, Kazunori Nishimura, Norio Sakurai, Kengo Imai, Naoki Matsuo, Naoko Takahashi, Kenichiro Okamoto, Akihiko Suga, Hiromi Sano, Isseki Maeda, Haruhiro Nishina, Takuhiro Yamaguchi, Tatsuya Morita, Satoru Iwase

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Nausea and vomiting are among the most common and distressing symptoms in patients with advanced cancer. Olanzapine, an antipsychotic agent, is known to have an affinity for multiple neurotransmitter receptors. Previous studies have reported olanzapine to be efficacious in the treatment of nausea and vomiting. Although it has been administered at a number of facilities, its applicability to treat nausea and vomiting in patients with advanced cancer is poorly understood. We investigated the use of olanzapine for nausea and vomiting in patients with advanced cancer at multiple centers. This retrospective study was carried out at seven palliative care units and three facilities with palliative care teams in Japan from 2013 to 2015. The dosage of olanzapine, treatment duration, and duration from initial use until death were collected from the medical records. One hundred and eight patients met our inclusion criteria. The average dose of olanzapine was 3.6 mg (2.5 mg, n = 61; 5 mg, n = 46; 10 mg, n = 1) and average treatment duration was 18.7 days. The average duration from initial use until death was 39.0 days. There were no differences in the duration of administration until death between olanzapine doses (2.5 and 5 mg). Our results suggest that olanzapine have been used in patients with poor prognoses for nausea and vomiting in patients with advanced cancer. Conducting a prospective trial would further yield promising results.

Original languageEnglish
Pages (from-to)2393-2395
Number of pages3
JournalSupportive Care in Cancer
Volume24
Issue number6
DOIs
Publication statusPublished - 2016 Jun 1
Externally publishedYes

Keywords

  • Cancer
  • Nausea
  • Olanzapine
  • Palliative care
  • Vomiting

ASJC Scopus subject areas

  • Oncology

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