Use of In Vivo Insert Molding to Form a Jellyfish Valve Leaflet

Ayumi Kishi, Takashi Isoyama, Itsuro Saito, Hidekazu Miura, Hidemoto Nakagawa, Akimasa Kouno, Toshiya Ono, Yusuke Inoue, Sachiko Yamaguchi, Wei Shi, Yusuke Abe, Kou Imachi, Makoto Noshiro

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


We developed an in vivo insert molding technique to form tissue-derived biomaterials into the desired shape, and with sufficient strength and durability, for use in artificial organs. Molds of acrylic resin with inserted velour cloth were implanted under the skin of goats to form a circular leaflet for a jellyfish valve. The valve leaflets were successfully produced in the molds after 17-60 days. Dense connective tissue covered the velour cloth, and loose connective tissue was formed within it. Tissue was radially formed from the hole in the mold. The tissue was simultaneously formed and shrunk. It is necessary to increase the connected portion between the tissue inside and outside the mold so that the tissue can completely cover the inserted materials without shrinkage.

Original languageEnglish
Pages (from-to)1125-1131
Number of pages7
JournalArtificial Organs
Issue number12
Publication statusPublished - 2010 Dec


  • In vivo
  • Insert molding technique
  • Jellyfish valve
  • Tissue

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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