TY - JOUR
T1 - Use of glucose solution for the alleviation of gemcitabine-induced vascular pain
T2 - A double-blind randomized crossover study
AU - Nagai, Hiroki
AU - Kitano, Toshiyuki
AU - Nishimura, Takafumi
AU - Yasuda, Hiroyasu
AU - Nakata, Kazumi
AU - Takashima, Sachie
AU - Kanai, Masashi
AU - Matsumoto, Shigemi
AU - Mori, Yukiko
AU - Kakudo, Yuichi
AU - Sato, Hiroyasu
AU - Yamaguchi, Takuhiro
AU - Kameno, Kaoru
AU - Kim, Young Hak
AU - Mishima, Michiaki
AU - Yanagihara, Kazuhiro
N1 - Funding Information:
Acknowledgments We would like to thank Prof. Masanori Fukushima for his invaluable advices and critical reading of the manuscript. This study was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture (Grant no.19689018) of the Japanese government. We thank all the patients and medical staff of Kyoto University Hospital and Tohoku University Hospital who participated in this study.
PY - 2013/12
Y1 - 2013/12
N2 - Purpose: Gemcitabine is widely used for chemotherapy in many types of cancers. However, vascular pain frequently occurs during its infusion, which can be serious enough to cause treatment discontinuation. This study was conducted to determine whether dissolution with 5 % glucose solution would relieve vascular pain compared with the approved use of saline as the diluent. Methods: Patients with cancer who were treated with weekly gemcitabine were eligible. Vascular pain was assessed during two consecutive administrations in a double-blind, randomized crossover study. One group was scheduled to receive gemcitabine dissolved in saline followed by gemcitabine in 5 % glucose solution. In the other group, 5 % glucose solution was followed by saline. The primary endpoint was frequency of vascular pain for the total infusions of each solvent and the secondary endpoints were intensity, as assessed on a visual analogue scale and duration of vascular pain. Results: Eighty-seven patients were randomly assigned to each treatment schedule. Frequency of vascular pain was significantly lower with 5 % glucose solution compared with saline (40 versus 63 %; p < 0.001). The intensity of vascular pain was also reduced with 5 % glucose solution compared with saline (mean, 1.3 versus 2.7 points; p < 0.001). There was no significant statistical difference in duration of vascular pain between the 5 % glucose solution and saline solution groups (mean, 21 versus 18 min; p = 0.420). Conclusions: The use of 5 % glucose solution to dissolve gemcitabine significantly reduced the frequency and the intensity of vascular pain compared with the use of saline.
AB - Purpose: Gemcitabine is widely used for chemotherapy in many types of cancers. However, vascular pain frequently occurs during its infusion, which can be serious enough to cause treatment discontinuation. This study was conducted to determine whether dissolution with 5 % glucose solution would relieve vascular pain compared with the approved use of saline as the diluent. Methods: Patients with cancer who were treated with weekly gemcitabine were eligible. Vascular pain was assessed during two consecutive administrations in a double-blind, randomized crossover study. One group was scheduled to receive gemcitabine dissolved in saline followed by gemcitabine in 5 % glucose solution. In the other group, 5 % glucose solution was followed by saline. The primary endpoint was frequency of vascular pain for the total infusions of each solvent and the secondary endpoints were intensity, as assessed on a visual analogue scale and duration of vascular pain. Results: Eighty-seven patients were randomly assigned to each treatment schedule. Frequency of vascular pain was significantly lower with 5 % glucose solution compared with saline (40 versus 63 %; p < 0.001). The intensity of vascular pain was also reduced with 5 % glucose solution compared with saline (mean, 1.3 versus 2.7 points; p < 0.001). There was no significant statistical difference in duration of vascular pain between the 5 % glucose solution and saline solution groups (mean, 21 versus 18 min; p = 0.420). Conclusions: The use of 5 % glucose solution to dissolve gemcitabine significantly reduced the frequency and the intensity of vascular pain compared with the use of saline.
KW - 5 % glucose solution
KW - Crossover
KW - Gemcitabine
KW - Saline
KW - Vascular pain
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U2 - 10.1007/s00520-013-1901-9
DO - 10.1007/s00520-013-1901-9
M3 - Article
C2 - 23877927
AN - SCOPUS:84889094744
SN - 0941-4355
VL - 21
SP - 3271
EP - 3278
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
IS - 12
ER -