Use of abasic site-containing DNA for electrochemical SNPs detection.

Kotaro Morita, Seiichi Nishizawa, Norio Teramae

Research output: Contribution to journalArticle

Abstract

In combination with an electrode modified with an abasic site-containing DNA duplex, flavins selectively bind to thymine with a useful electrochemical response, and flavins could be successfully utilized for detection of thymine-related mutations. The abasic site provides hydrophobic microenvironments for the hydrogen bond-forming ligands can recognize the specific target base in the DNA duplex, which is detected by the difference in the electrochemical response.

Original languageEnglish
Pages (from-to)91-92
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number50
Publication statusPublished - 2006 Jan 1

ASJC Scopus subject areas

  • Medicine(all)

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